Incidence of Cystic Fibrosis in Saguenay-Lac-St.-Jean (Quebec, Canada)

The incidence of cystic fibrosis (CF) in Saguenay-Lac-St.-Jean, a geographically isolated region of Quebec, was estimated to be 1 in 902 during the period 1975-1988. The carrier rate was calculated to be 1 in 15 inhabitants. The high incidence of CF in Saguenay-Lac-St.-Jean is probably the result of...

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Bibliographic Details
Published in:Human biology 1992-02, Vol.64 (1), p.115-119
Main Authors: DAIGNEAULT, JOCELYNE, AUBIN, GERVAIS, SIMARD, FERNAND, DE BRAEKELEER, MARC
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brief Communications
Carrier State - epidemiology
Catholicism
Cystic fibrosis
Cystic Fibrosis - diagnosis
Cystic Fibrosis - epidemiology
Cystic Fibrosis - genetics
Demographics
Disease
Disease sex factors
Emigration and Immigration
European Continental Ancestry Group
Founder effect
France - ethnology
Gastroenterology. Liver. Pancreas. Abdomen
Gene Frequency
Gene Pool
Genetic aspects
Genetic disorders
Genetic mutation
Genetics
Genomes
Geographic regions
Humans
Immigration
Incidence
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical research
Medical sciences
Metagenomics
Other diseases. Semiology
Population genetics
Quebec - epidemiology
Sex factors in disease
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Summary:The incidence of cystic fibrosis (CF) in Saguenay-Lac-St.-Jean, a geographically isolated region of Quebec, was estimated to be 1 in 902 during the period 1975-1988. The carrier rate was calculated to be 1 in 15 inhabitants. The high incidence of CF in Saguenay-Lac-St.-Jean is probably the result of a founder effect and genetic drift for one or more mutations. Historical, demographic, and social factors also may have contributed to the high incidence.
ISSN:0018-7143
1534-6617