GM and KM Allotypes and GM RFLP Allogenotypes in Micronesians from Nauru

Immunoglobulin allotypes of the GM and KM systems were determined in a sample of Micronesian subjects from Nauru.our GM haplotypes were identified in the sample: GM* 1,3 23 5, 10,11,13,14, GM* 1,17 23' 21, GM* 1,3 23' 5,10,11,13,14, and GM* 1,2,17 23' 21, although the last of these ma...

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Bibliographic Details
Published in:Human biology 1992-02, Vol.64 (1), p.17-24
Main Authors: PROPERT, DAVID N., NANDAN, ROHAN, JAZWINSKA, ELIZABETH C.
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetics
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Haplotypes
History
Human
Human genetics
Human population genetics
Humans
Immunoglobulin Allotypes
Immunoglobulin Gm Allotypes - genetics
Immunoglobulin kappa-Chains - genetics
Immunoglobulins
Km allotypes
Medical genetics
Micronesia
Minority & ethnic groups
Oceanians
Pacific Islanders
Phenotype
Phenotypes
Physiological aspects
Polymorphism, Restriction Fragment Length
Population genetics, reproduction patterns
Restriction fragment length polymorphism
Tropical medicine
White people
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Summary:Immunoglobulin allotypes of the GM and KM systems were determined in a sample of Micronesian subjects from Nauru.our GM haplotypes were identified in the sample: GM* 1,3 23 5, 10,11,13,14, GM* 1,17 23' 21, GM* 1,3 23' 5,10,11,13,14, and GM* 1,2,17 23' 21, although the last of these may have been introduced by non-Micronesian admixture. The frequency of the KM* 1 allele is 0.115 ± 0.033, which is slightly lower than reported in Micronesians from the Caroline Islands. RFLPs generated by the enzymes Taq I and Pvu II and detected by a Huγ₄ probe were related to GM phenotypes. The haplotypes GM* 1,3 ± 23 5,10,11,13,14 were strongly associated with a Taq I 5.0-kb band. The presence and absence of the allotype G2M 23 were marked by a Pvu II 7.0 + 2.0 kb pair and a Pvu II 9.0-kb fragment, respectively.GM* 1,17 23' 21 was strongly associated with a Pvu II 5.0 + 2.7 kb pair. The different relationships between GM haplotypes and Hu7 4 RFLPs in Micronesians and Caucasians indicate that a universal GM allogenotyping procedure cannot yet be developed; instead, population-specific procedures are necessitated by differences in GM allotype arrangements between populations.
ISSN:0018-7143
1534-6617