Tube or Not Tube: Remodeling Epithelial Tissues by Branching Morphogenesis

Branching morphogenesis involves the restructuring of epithelial tissues into complex and organized ramified tubular networks. Early rounds of branching are controlled genetically in a hardwired fashion in many organs, whereas later, branching is stochastic, responding to environmental cues. We disc...

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Bibliographic Details
Published in:Developmental Cell 2003, Vol.4 (1), p.11-18
Main Authors: Affolter, Markus, Bellusci, Savério, Itoh, Nobuyuki, Shilo, Benny, Thiery, Jean-Paul, Werb, Zena
Format: Article
Language:English
Subjects:
Animals
Breast - cytology
Breast - embryology
Cell Differentiation
Cell Movement
Epithelium - embryology
Humans
Kidney - cytology
Kidney - embryology
Lung - cytology
Lung - embryology
Morphogenesis
Organ Specificity
Trachea - cytology
Trachea - embryology
Online Access:Get full text
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Summary:Branching morphogenesis involves the restructuring of epithelial tissues into complex and organized ramified tubular networks. Early rounds of branching are controlled genetically in a hardwired fashion in many organs, whereas later, branching is stochastic, responding to environmental cues. We discuss this sequential process from formation of an organ anlage and invagination of the epithelium to branch initiation and outgrowth in several model systems including Drosophila trachea and mammalian lung, mammary gland, and kidney.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(02)00410-0