Apoptosis and Programmed Cell Death in Immunity

Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They under...

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Bibliographic Details
Published in:Annual review of immunology 1992, Vol.10 (1), p.267-293
Main Authors: Cohen, J. John, Duke, Richard C, Fadok, Valerie A, Sellins, Karen S
Format: Article
Language:English
Subjects:
activation-induced death
Ageing, cell death
Animals
apoptosis
Biological and medical sciences
cell death
Cell Death - immunology
Cell physiology
CTL
DNA - metabolism
DNA fragmentation
Fundamental and applied biological sciences. Psychology
glucocorticoids
Humans
Lymphocytes - cytology
Lymphocytes - immunology
Lymphocytes - metabolism
Molecular and cellular biology
Phagocytosis
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Summary:Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They undergo shrinkage and zeiosis, the nucleus collapses, and chromatin is cleaved into nucleosomal fragments. The cell is rapidly recognized by phagocytes and disposed of without releasing its contents. In some but not all cases of apoptosis, new macromolecular synthesis is required. Cytotoxic T cells induce changes in their targets that are morphologically apoptotic. The mechanism ofapoptosis is currently under active investigation.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.iy.10.040192.001411