Ovarian response, embryo production and hormonal profile in superovulated goats treated with insulin

• Published in: Theriogenology 2003-03, Vol.59 (5), p.1459-1468
• Main Authors: Selvaraju, S., Agarwal, S.K., Karche, S.D., Majumdar, A.C.
• Format: Article
• Language: English
• Subjects: Animals; Blood Glucose - metabolism; Embryo quality; Embryonic and Fetal Development - drug effects; Embryonic and Fetal Development - physiology; Estradiol - blood; Estradiol-17β; Estrus - physiology; Female; Goat; Goats - embryology; Goats - physiology; Insulin; Insulin - pharmacology; Male; Ovarian Follicle - drug effects; Ovarian Follicle - metabolism; Ovarian Follicle - physiology; Ovarian response; Pregnancy; Progesterone; Progesterone - blood; Random Allocation; Superovulation - physiology
• ISSN: 0093-691X; 1879-3231
• DOI: 10.1016/S0093-691X(02)01196-2

The influence of insulin on ovarian response and embryo production was investigated in 30 mixed breed goats, divided randomly into three equal ( n=10) groups. Goats in Group 1 (control) were superovulated using 20 IU FSH i.m. in six divided descending doses, i.e. 4/4, 3/3 and 3/3 IU at 12 h interval for three consecutive days and were not given insulin treatment. Goats in Group 2 (insulin pretreatment) were pretreated with long acting purified bovine insulin 0.2 IU/kg body weight per day s.c. on Days 7, 8 and 9 of the estrous cycle prior to initiation of superovulatory treatment as in Group 1. Animals in Group 3 (insulin cotreatment) were treated as in Group I, but in addition received long acting purified bovine insulin 0.2 IU/kg body weight per day s.c. as a cotreatment along with the first, third and fifth FSH treatments on three consecutive days. Total ovarian response (corpus luteum and unovulated large follicle (UOLF)) was significantly ( P