Does Inflammation or Undernutrition Explain the Low Cholesterol-Mortality Association in High-Functioning Older Persons? MacArthur Studies of Successful Aging

OBJECTIVES: To explore the effect of inflammation and undernutrition on the association between hypocholesterolemia and higher overall mortality in high‐functioning older persons. DESIGN: Prospective cohort study. SETTING: Three U.S. communities. PARTICIPANTS: A cohort of 870 participants from the M...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2003-01, Vol.51 (1), p.80-84
Main Authors: Hu, Peifeng, Seeman, Teresa E., Harris, Tamara B., Reuben, David B.
Format: Article
Language:English
Subjects:
Aged
aging
Biological and medical sciences
Body Mass Index
Cause of Death
Cholesterol
Cholesterol - blood
Development. Metamorphosis. Moult. Ageing
Elderly people
Epidemiologic Studies
Female
Fundamental and applied biological sciences. Psychology
Geriatric Assessment
Health Status
Humans
inflammation
Inflammation - mortality
Logistic Models
Male
Malnutrition
Mortality
Nutrition Disorders - blood
Nutrition Disorders - mortality
Older people
Prospective Studies
Risk Factors
Serum Albumin - deficiency
serum total cholesterol
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:OBJECTIVES: To explore the effect of inflammation and undernutrition on the association between hypocholesterolemia and higher overall mortality in high‐functioning older persons. DESIGN: Prospective cohort study. SETTING: Three U.S. communities. PARTICIPANTS: A cohort of 870 participants from the MacArthur Studies of Successful Aging. MEASUREMENTS: Baseline information was obtained for serum levels of cholesterol, C‐reactive protein, interleukin‐6, and albumin; body mass index; prevalent medical conditions; health behaviors; and medications. Crude and multivariate logistic regression analyses were used to examine the association between serum total cholesterol levels and 7‐year all‐cause mortality, while adjusting for potential confounders. RESULTS: In univariate analysis, the risk ratio of low serum total cholesterol level (
ISSN:0002-8614
1532-5415
DOI:10.1034/j.1601-5215.2002.51014.x