10'-DESMETHOXYSTREPTONIGRIN, A NOVEL ANALOG OF STREPTONIGRIN

10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of RAS p21 protein. The compound was isolated from the fermentation broth and its structure determined. It is markedly cytotoxic to several hum...

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Bibliographic Details
Published in:Journal of antibiotics 1992/04/25, Vol.45(4), pp.454-457
Main Authors: Liu, W. C., BARBACID, M., BULGAR, M., CLARK, J. M., CROSSWELL, A. R., DEAN, L., DOYLE, T. W., FERNANDES, P. B., HUANG, S., MANNE, V., PIRNIK, D. M., WELLS, J. S., MEYERS, and E.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, Antineoplastic - chemistry
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacteria - drug effects
Bacteriological Techniques
Biological and medical sciences
Bone Marrow - drug effects
Colonic Neoplasms - drug therapy
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Spectroscopy
Mice
Microbial Sensitivity Tests
Microbiology
Spectrophotometry, Infrared
Streptomyces - chemistry
Streptomyces albus
Streptonigrin - analogs & derivatives
Streptonigrin - chemistry
Streptonigrin - isolation & purification
Streptonigrin - pharmacology
Tumor Cells, Cultured
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Summary:10'-Desmethoxystreptonigrin, a novel analog of streptonigrin produced by Streptomyces albus, was discovered in a screen for inhibitors of farnesylation of RAS p21 protein. The compound was isolated from the fermentation broth and its structure determined. It is markedly cytotoxic to several human tumor cell lines and also exhibits potent broad-spectrum antibacterial activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.45.454