Phocine distemper virus, the agent responsible for the 1988 mass mortality of seals

The biochemical characterisation of phocine distemper virus (PDV) has shown that PDV is related to but clearly distinct from canine distemper virus (CDV) and relative to its relationship with CDV is only remotely related to the other morbilliviruses, namely measles virus (MV) or rinderpest virus (RP...

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Bibliographic Details
Published in:The Science of the total environment 1992-04, Vol.115 (1), p.45-55
Main Authors: Rima, B.K., Curran, M.D., Kennedy, S.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
canine distemper virus
Distemper - microbiology
Distemper - mortality
Distemper Virus, Canine - classification
Distemper Virus, Canine - genetics
Genome, Viral
Marine
Measles virus - classification
monoclonal antibodies
morbillivirus
Paramyxoviridae - classification
Paramyxoviridae - genetics
Paramyxoviridae - pathogenicity
Phocine distemper virus
Phylogeny
Pinnipedia
proteins
RNA, Viral - genetics
RNA, Viral - isolation & purification
seals
Seals, Earless - microbiology
Viral Proteins - genetics
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Summary:The biochemical characterisation of phocine distemper virus (PDV) has shown that PDV is related to but clearly distinct from canine distemper virus (CDV) and relative to its relationship with CDV is only remotely related to the other morbilliviruses, namely measles virus (MV) or rinderpest virus (RPV) and peste-des-petits-ruminants virus (PPRV). Comparative studies with monoclonal antibodies indicate that the virus is serologically closely related to CDV with many conserved epitopes, particularly on the internal proteins of the virus, while the external attachment (H) protein shows the greatest level of variability among the distemper virus isolates. The analysis of the viral proteins by electrophoresis indicates molecular weight differences between CDV and PDV in the fusion (F), phosphoprotein (P), H, nucleocapsid (N) and matrix (M) proteins. The RNA profiles of CDV and PDV are indistinguishable and different from those for RPV and MV. Nucleotide sequence analysis of cDNA clones of the virus show approximately 70% homology between CDV and PDV and approximately 48% with MV. These data prove that PDV is a different virus from CDV and co-circulates with it probably primarily in sea mammals.
ISSN:0048-9697
1879-1026
DOI:10.1016/0048-9697(92)90031-M