Effects of polyphenolic fraction of silymarin on lipoprotein profile in rats fed cholesterol-rich diets

To study the influence of polymerised polyphenolics (PP), a fraction of silymarin (SM), on lipids and oxidant status, rats were fed high-cholesterol (1%), high-fat (10%) diets containing either lard fat (LFD) rich in saturated/monounsaturated fatty acids, or currant oil (COD) rich in polyunsaturated...

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Published in:Pharmacological research 2003, Vol.47 (1), p.17-26
Main Authors: Škottová, Nina, Večeřa, Rostislav, Urbánek, Karel, Váňa, Petr, Walterová, Daniela, Cvak, Ladislav
Format: Article
Language:English
Subjects:
Animals
Antioxidant status
Cholesterol, Dietary - metabolism
Cholesterol, Dietary - pharmacology
Dietary Fats - pharmacology
Flavonoids
Lipoprotein profile
Lipoproteins - blood
Liver - drug effects
Liver - metabolism
Liver lipids
Male
Phenols - pharmacology
Polymerised polyphenolics
Polymers - pharmacology
Rats
Rats, Wistar
Silymarin
Silymarin - pharmacology
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Summary:To study the influence of polymerised polyphenolics (PP), a fraction of silymarin (SM), on lipids and oxidant status, rats were fed high-cholesterol (1%), high-fat (10%) diets containing either lard fat (LFD) rich in saturated/monounsaturated fatty acids, or currant oil (COD) rich in polyunsaturated fatty acids. PP and SM were administered as dietary supplements (0.1–0.5–1.0%) for 3 weeks. PP (1%) decreased cholesterol (C) in VLDL (from 0.72±0.08 mmol l −1 in LFD control to 0.35±0.07 mmol l −1, P
ISSN:1043-6618
1096-1186
DOI:10.1016/S1043-6618(02)00252-9