Animal models of allergic asthma

We are fortunate to have many species of animals that can serve as adequate models for allergic disease in humans. This review is focused mostly on models of allergic airway disease, and some major categories of animals used for asthma research are discussed, including rodents and nonhuman primates....

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Bibliographic Details
Published in:Current allergy and asthma reports 2003-01, Vol.3 (1), p.70-78
Main Authors: Isenberg-Feig, Heidi, Justice, J Paul, Keane-Myers, Andrea
Format: Article
Language:English
Subjects:
Allergies
Animals
Asthma
Asthma - etiology
Asthma - physiopathology
Bronchial Hyperreactivity - etiology
Bronchial Hyperreactivity - physiopathology
Disease Models, Animal
Humans
Medical research
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Summary:We are fortunate to have many species of animals that can serve as adequate models for allergic disease in humans. This review is focused mostly on models of allergic airway disease, and some major categories of animals used for asthma research are discussed, including rodents and nonhuman primates. Furthermore, evidence that supports and criticizes the use of animal models of asthma is provided. There is no animal model that exactly reproduces the pathology of human asthma. However, these models are necessary for the development of novel therapies and an understanding of the detailed pathogenesis of the response of mammals to respirable allergens.
ISSN:1529-7322
1534-6315
DOI:10.1007/s11882-003-0015-8