Tyrosol and hydroxytyrosol are absorbed from moderate and sustained doses of virgin olive oil in humans

Objective : To investigate the absorption of tyrosol and hydroxytyrosol from moderate and sustained doses of virgin olive oil consumption. The study also aimed to investigate whether these phenolic compounds could be used as biomarkers of virgin olive oil intake. Design and interventions : Ingestion...

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Bibliographic Details
Published in:European Journal of Clinical Nutrition 2003-01, Vol.57 (1), p.186-190
Main Authors: Miró-Casas, E, Covas, M-I, Fitó, M, Farré-Albadalejo, M, Marrugat, J, de la Torre, R
Format: Article
Language:English
Subjects:
Absorption
Adult
Antioxidants - pharmacokinetics
Biological and medical sciences
Biomarkers - urine
Carbon dioxide
Clinical Nutrition
Diet
Diet Records
Dose-response effects
Dose-Response Relationship, Drug
Effects
Epidemiology
Female
Human physiology applied to population studies and life conditions. Human ecophysiology
Humans
Ingestion
Internal Medicine
Intestinal Absorption
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Clearance Rate
Metabolic Diseases
Middle Aged
Miscellaneous. Technology
Nutritional survey. Food supply and nutritional requirement
Nutritive Value
Oils & fats
Olive Oil
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phenols
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacokinetics
Phenylethyl Alcohol - urine
Plant Oils - chemistry
Public Health
short-communication
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Summary:Objective : To investigate the absorption of tyrosol and hydroxytyrosol from moderate and sustained doses of virgin olive oil consumption. The study also aimed to investigate whether these phenolic compounds could be used as biomarkers of virgin olive oil intake. Design and interventions : Ingestion of a single dose of virgin olive oil (50 ml). Thereafter, for a week, participants followed their usual diet which included 25 ml/day of the same virgin olive oil as the source of raw fat. Setting : Unitat de Recerca en Farmacologia. Institut Municipal d'Investigació Mèdica (IMIM). Subjects : Seven healthy volunteers. Results : An increase in 24 h urine of tyrosol and hydroxytyrosol, after both a single-dose ingestion (50 ml) and short-term consumption (one week, 25 ml/day) of virgin olive oil ( P
ISSN:0954-3007
1476-5381
1476-5640
DOI:10.1038/sj.ejcn.1601532