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Liposomes and ISCOMs
Liposomes and ISCOMs have a long history as vehicles for antigen delivery. Liposomes can carry both membrane associated antigens as well as water soluble molecules. Their physical properties are highly variable, depending on composition and manufacturing method. This allows optimised design for spec...
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| Published in: | Vaccine 2003-02, Vol.21 (9), p.915-920 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c535t-3aae388faf1439f96902e81c447a618f4e8c1ad9775789712994f2eed4049f063 |
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| container_end_page | 920 |
| container_issue | 9 |
| container_start_page | 915 |
| container_title | Vaccine |
| container_volume | 21 |
| creator | Kersten, Gideon F.A Crommelin, Daan J.A |
| description | Liposomes and ISCOMs have a long history as vehicles for antigen delivery. Liposomes can carry both membrane associated antigens as well as water soluble molecules. Their physical properties are highly variable, depending on composition and manufacturing method. This allows optimised design for specific tasks (targeting, co-incorporation of adjuvants, etc.). ISCOMs already have a build-in adjuvant,
Quillaja saponin, which is a structural part of the vehicle. In recent years, considerable progress has been achieved with respect to the use of better defined saponin. Clinical trials with ISCOMs are in progress and registered liposomal vaccines exist. Here, follows a brief overview on recent developments with emphasis on pharmaceutical aspects. |
| doi_str_mv | 10.1016/S0264-410X(02)00540-6 |
| format | article |
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Quillaja saponin, which is a structural part of the vehicle. In recent years, considerable progress has been achieved with respect to the use of better defined saponin. Clinical trials with ISCOMs are in progress and registered liposomal vaccines exist. Here, follows a brief overview on recent developments with emphasis on pharmaceutical aspects.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(02)00540-6</identifier><identifier>PMID: 12547602</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Adjuvants, Immunologic - chemistry ; Animals ; Antigens - administration & dosage ; B-Lymphocytes - immunology ; Biological and medical sciences ; Cholesterol ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Hepatitis ; Humans ; Immunobiology ; Influenza ; ISCOMs ; ISCOMs - administration & dosage ; ISCOMs - chemistry ; Lipids ; Liposomes ; Liposomes - chemistry ; Microscopy, Electron ; Modulation of the immune response (stimulation, suppression) ; Molecular Structure ; Phase transitions ; Physical properties ; Product development ; Proteins ; Quillaja Saponins ; Saponins - administration & dosage ; Saponins - chemistry ; T-Lymphocytes - immunology ; Vaccines ; Vaccines - administration & dosage ; Virosomes ; Virosomes - chemistry</subject><ispartof>Vaccine, 2003-02, Vol.21 (9), p.915-920</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 14, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-3aae388faf1439f96902e81c447a618f4e8c1ad9775789712994f2eed4049f063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14733800$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12547602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kersten, Gideon F.A</creatorcontrib><creatorcontrib>Crommelin, Daan J.A</creatorcontrib><title>Liposomes and ISCOMs</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Liposomes and ISCOMs have a long history as vehicles for antigen delivery. Liposomes can carry both membrane associated antigens as well as water soluble molecules. Their physical properties are highly variable, depending on composition and manufacturing method. This allows optimised design for specific tasks (targeting, co-incorporation of adjuvants, etc.). ISCOMs already have a build-in adjuvant,
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Psychology</topic><topic>Fundamental immunology</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Influenza</topic><topic>ISCOMs</topic><topic>ISCOMs - administration & dosage</topic><topic>ISCOMs - chemistry</topic><topic>Lipids</topic><topic>Liposomes</topic><topic>Liposomes - chemistry</topic><topic>Microscopy, Electron</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Molecular Structure</topic><topic>Phase transitions</topic><topic>Physical properties</topic><topic>Product development</topic><topic>Proteins</topic><topic>Quillaja Saponins</topic><topic>Saponins - administration & dosage</topic><topic>Saponins - chemistry</topic><topic>T-Lymphocytes - immunology</topic><topic>Vaccines</topic><topic>Vaccines - administration & dosage</topic><topic>Virosomes</topic><topic>Virosomes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kersten, Gideon F.A</creatorcontrib><creatorcontrib>Crommelin, Daan J.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>Proquest Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kersten, Gideon F.A</au><au>Crommelin, Daan J.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liposomes and ISCOMs</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2003-02-14</date><risdate>2003</risdate><volume>21</volume><issue>9</issue><spage>915</spage><epage>920</epage><pages>915-920</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Liposomes and ISCOMs have a long history as vehicles for antigen delivery. Liposomes can carry both membrane associated antigens as well as water soluble molecules. Their physical properties are highly variable, depending on composition and manufacturing method. This allows optimised design for specific tasks (targeting, co-incorporation of adjuvants, etc.). ISCOMs already have a build-in adjuvant,
Quillaja saponin, which is a structural part of the vehicle. In recent years, considerable progress has been achieved with respect to the use of better defined saponin. Clinical trials with ISCOMs are in progress and registered liposomal vaccines exist. Here, follows a brief overview on recent developments with emphasis on pharmaceutical aspects.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12547602</pmid><doi>10.1016/S0264-410X(02)00540-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Vaccine, 2003-02, Vol.21 (9), p.915-920 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - chemistry Animals Antigens - administration & dosage B-Lymphocytes - immunology Biological and medical sciences Cholesterol Fundamental and applied biological sciences. Psychology Fundamental immunology Hepatitis Humans Immunobiology Influenza ISCOMs ISCOMs - administration & dosage ISCOMs - chemistry Lipids Liposomes Liposomes - chemistry Microscopy, Electron Modulation of the immune response (stimulation, suppression) Molecular Structure Phase transitions Physical properties Product development Proteins Quillaja Saponins Saponins - administration & dosage Saponins - chemistry T-Lymphocytes - immunology Vaccines Vaccines - administration & dosage Virosomes Virosomes - chemistry |
| title | Liposomes and ISCOMs |
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