Region-Specific Apoptosis Limits Neural Stem Cell Proliferation

Regulation of stem cell division is of particular interest, both for studies of development and for stem cell therapeutics. In this issue of Neuron, Bello et al. show that the number of divisions of Drosophila neural stem cells is limited, in a region-specific manner, by regulated apoptosis in respo...

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Bibliographic Details
Published in:Neuron 2003-01, Vol.37 (2), p.185-187
Main Authors: Brand, Andrea H., van Roessel, Peter J.
Format: Article
Language:English
Subjects:
Abdomen
Animals
Apoptosis
Apoptosis - physiology
Cell cycle
Cell Division
Cell Lineage
Drosophila
Mitosis - physiology
Neurons - physiology
Stem cells
Stem Cells - physiology
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Summary:Regulation of stem cell division is of particular interest, both for studies of development and for stem cell therapeutics. In this issue of Neuron, Bello et al. show that the number of divisions of Drosophila neural stem cells is limited, in a region-specific manner, by regulated apoptosis in response to a pulse of expression of the Hox gene abdominal-A ( abdA).
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(03)00026-6