Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass

The objective of this study was to evaluate the influence of the molecular mass and accordingly the polymer chain length on mucoadhesion and cohesion of thiolated polymers. Linear poly(acrylic acid)-cysteine (PAA-Cys) conjugates of 2-, 45-, 250- and 450 kDa (PAA 2-Cys, PAA 45-Cys, PAA 250-Cys and PA...

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Bibliographic Details
Published in:European journal of pharmaceutical sciences 2003, Vol.18 (1), p.89-96
Main Authors: Leitner, V.M, Marschütz, M.K, Bernkop-Schnürch, A
Format: Article
Language:English
Subjects:
Acrylic Resins - chemistry
Animals
Biological and medical sciences
Chemistry, Pharmaceutical
Cysteine - chemistry
Drug Compounding - methods
Gastric Mucins - chemistry
Gastric Mucins - physiology
General pharmacology
In Vitro Techniques
Intestinal Mucosa - physiology
Medical sciences
Molecular mass
Molecular Weight
Mucoadhesion
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Poly(acrylic acid)
Swine
Tablets
Tensile Strength
Thiomers
Time Factors
Tissue Adhesions
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Summary:The objective of this study was to evaluate the influence of the molecular mass and accordingly the polymer chain length on mucoadhesion and cohesion of thiolated polymers. Linear poly(acrylic acid)-cysteine (PAA-Cys) conjugates of 2-, 45-, 250- and 450 kDa (PAA 2-Cys, PAA 45-Cys, PAA 250-Cys and PAA 450-Cys) and polycarbophil-cysteine (PCP-Cys, 750–3000 kDa), all displaying on average 404.1±65.5 μMol thiol groups per gram polymer were compressed into tablets to perform disintegration tests, mucoadhesion studies and viscosity measurements. Moreover, the influence of free unbound cysteine on mucoadhesion was evaluated. Disintegration tests showed a stability of the tablets as following: PAA 2-Cys
ISSN:0928-0987
1879-0720
DOI:10.1016/S0928-0987(02)00245-2