Blood extracellular superoxide dismutase levels in hemodialysis patients pre- and post-hemodialysis and its association with lipoprotein lipase mass and free fatty acid

Background: Hemodialysis (HD) is a method of chronic therapy for patients with renal failure. Diabetic nephropathy is the most common underlying disease among HD patients in Japan. A characteristic problem associated with this condition is endothelial cell damage. We have been using extracellular su...

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Bibliographic Details
Published in:Clinica chimica acta 2003-02, Vol.328 (1), p.113-119
Main Authors: Shimomura, Hiroji, Maehata, Eisuke, Takamiya, Tomi, Adachi, Tetsuo, Komoda, Tsugikazu
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antimicrobial Cationic Peptides
Biological and medical sciences
Blood Proteins
Carrier Proteins - blood
Emergency and intensive care: renal failure. Dialysis management
Endothelium, Vascular - pathology
Extracellular Space - enzymology
Extracellular-superoxide dismutase
Fatty Acids, Nonesterified - blood
Female
Free fatty acid
Hemodialysis
Humans
Intensive care medicine
Lipoprotein Lipase - blood
Lipoprotein lipase mass
Male
Medical sciences
Middle Aged
Oxidative stress
Renal Dialysis - adverse effects
Superoxide Dismutase - blood
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Summary:Background: Hemodialysis (HD) is a method of chronic therapy for patients with renal failure. Diabetic nephropathy is the most common underlying disease among HD patients in Japan. A characteristic problem associated with this condition is endothelial cell damage. We have been using extracellular superoxide dismutase (EC-SOD) attached to the heparan sulfate on the endothelial cell surface as a marker of vascular damage. Methods: This study examined the pre- and post-HD levels of lipoprotein lipase (LPL). The increase in free fatty acid (FFA) is affected by a type of cytokine-like substances, which induces insulin resistance and causes abnormal lipid metabolism. Results: Pre-HD blood samples showed highly significant correlations between EC-SOD and LPL mass ( r=0.792) and between EC-SOD and FFA ( r=0.675) ( p
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(02)00378-9