Successful vaccination of BALB/c mice against human hookworm ( Necatoramericanus): the immunological phenotype of the protective response

In this murine (BALB/c) model of necatoriasis, high levels of protection against challenge infection by Necator americanus larvae ( n=300) were afforded by successive vaccinations at 14-day intervals, either subcutaneously or percutaneously, with γ-irradiated N. americanus larvae ( n=300). Percutane...

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Bibliographic Details
Published in:International journal for parasitology 2003, Vol.33 (1), p.71-80
Main Authors: Girod, N, Brown, A, Pritchard, D.I, Billett, E.E
Format: Article
Language:English
Subjects:
Animals
Antibodies, Helminth - biosynthesis
Antigens, Helminth - immunology
Attenuated vaccine
Biological and medical sciences
Experimental helminthic diseases. Models
Fundamental and applied biological sciences. Psychology
Helminthic diseases
Hookworm
Humans
Immunoglobulin G - biosynthesis
Immunophenotyping
Infectious diseases
Interferon-gamma - biosynthesis
Interleukin-4 - biosynthesis
Intestines - parasitology
Invertebrates
Lung - parasitology
Male
Mast Cells - immunology
Medical sciences
Mice
Mice, Inbred BALB C
Necator americanus
Necator americanus - immunology
Necatoramericanus
Necatoriasis - immunology
Necatoriasis - parasitology
Necatoriasis - prevention & control
Nemathelminthia. Plathelmintha
Parasitic diseases
Skin - parasitology
Th2 phenotype
Vaccination - methods
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Attenuated - immunology
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Summary:In this murine (BALB/c) model of necatoriasis, high levels of protection against challenge infection by Necator americanus larvae ( n=300) were afforded by successive vaccinations at 14-day intervals, either subcutaneously or percutaneously, with γ-irradiated N. americanus larvae ( n=300). Percutaneous vaccination was significantly more effective than the subcutaneous route, with pulmonary larval burdens at 3 days post-infection being reduced by 97.8 vs. 89.3%, respectively, after three immunisations ( P
ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(02)00248-5