Prognostic value of serial cardiac assessment and familial screening in patients with dilated cardiomyopathy

Objectives: This prospective study was performed to analyse whether routine clinical follow‐up investigations at 12±6 months add to risk stratification and improve survival rates in patients with a first diagnosis of dilated cardiomyopathy (DCM). Methods: Four hundred and eighty consecutive patients...

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Bibliographic Details
Published in:European journal of heart failure 2003-01, Vol.5 (1), p.55-62
Main Authors: Grünig, Ekkehard, Benz, Andreas, Mereles, Derliz, Unnebrink, Kristina, Kücherer, Helmut, Haass, Markus, Kübler, Wolfgang, Katus, Hugo A.
Format: Article
Language:English
Subjects:
Adult
Aged
Ambulatory Care
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Cardiac Surgical Procedures
Cardiomyopathy, Dilated - diagnosis
Cardiomyopathy, Dilated - mortality
Cardiomyopathy, Dilated - therapy
dilated cardiomyopathy
Double-Blind Method
Electrocardiography
familial cardiomyopathy
Family Health
Female
Follow-Up Studies
genetics
Germany
Humans
Male
Middle Aged
Multivariate Analysis
Patient Compliance
Predictive Value of Tests
Prognosis
Prospective Studies
Pulmonary Wedge Pressure - physiology
serial assessment
Stroke Volume - physiology
survival
Survival Analysis
Treatment Outcome
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Summary:Objectives: This prospective study was performed to analyse whether routine clinical follow‐up investigations at 12±6 months add to risk stratification and improve survival rates in patients with a first diagnosis of dilated cardiomyopathy (DCM). Methods: Four hundred and eighty consecutive patients (mean age 53.4±12.3 years, 369 males, mean NYHA class 2.4±0.8) with invasively confirmed DCM were included and followed for 3.9±3.5 years. Patients were requested to adhere to a follow up investigation within 6–18 months either at the referring physicians or at our out patient department. Two hundred and eighty‐one of the 480 patients presented for follow up which consisted of a detailed evaluation of symptoms, standardized physical examination, 12‐lead‐electrocardiogram recording and echocardiography. Seventeen patients were lost for follow up, 182 did not seek specialized medical follow up. Patients outcome was assessed by structured telephone interviews. Results: Independent predictors of death or transplantation at initial diagnosis were LV–ejection fraction
ISSN:1388-9842
1879-0844
DOI:10.1016/S1388-9842(02)00179-4