Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat

Gamma frequency oscillations (30–100 Hz) have been suggested to underlie various cognitive and motor functions. Here, we examine the generation of gamma oscillation currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two gamma generators were identified, one in the dentate gy...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2003-01, Vol.37 (2), p.311-322
Main Authors: Csicsvari, Jozsef, Jamieson, Brian, Wise, Kensall D., Buzsáki, György
Format: Article
Language:English
Subjects:
Animals
Brain Mapping
Dentate Gyrus - physiology
Electric Stimulation
Electrodes, Implanted
Electrophysiology
Hippocampus - anatomy & histology
Hippocampus - cytology
Hippocampus - physiology
Interneurons - physiology
Male
Nerve Net - physiology
Neurons
Neurons - physiology
Rats
Rats, Sprague-Dawley
Rodents
Tetanus
Theta Rhythm
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Summary:Gamma frequency oscillations (30–100 Hz) have been suggested to underlie various cognitive and motor functions. Here, we examine the generation of gamma oscillation currents in the hippocampus, using two-dimensional, 96-site silicon probes. Two gamma generators were identified, one in the dentate gyrus and another in the CA3-CA1 regions. The coupling strength between the two oscillators varied during both theta and nontheta states. Both pyramidal cells and interneurons were phase-locked to gamma waves. Anatomical connectivity, rather than physical distance, determined the coupling strength of the oscillating neurons. CA3 pyramidal neurons discharged CA3 and CA1 interneurons at latencies indicative of monosynaptic connections. Intrahippocampal gamma oscillation emerges in the CA3 recurrent system, which entrains the CA1 region via its interneurons.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(02)01169-8