Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant–antioxidant system in patients with psoriasis

• Published in: Clinica chimica acta 2003-02, Vol.328 (1), p.71-82
• Main Authors: Vanizor Kural, Birgül, Örem, Asım, Çimşit, Gülseren, Yandı, Yunus Emre, Calapoǧlu, Mustafa
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants; Arteriosclerosis - etiology; Atherosclerosis (general aspects, experimental research); Autoantibodies against oxidized LDL; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Catalase - metabolism; Dermatology; Disease Susceptibility; Female; Humans; LDL oxidation; Lipid peroxidation; Lipids; Lipids - blood; Lipoproteins - blood; Lipoproteins, LDL - blood; Male; Medical sciences; Middle Aged; Oxidation-Reduction; Psoriasis; Psoriasis - complications; Psoriasis - metabolism; Psoriasis. Parapsoriasis. Lichen; Superoxide Dismutase - metabolism
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/S0009-8981(02)00373-X

Background: Psoriasis is a common chronic and recurrent inflammatory skin disease that can occur due to abnormalities in essential fatty acid metabolism, lymphokine secretion, free radical generation, lipid peroxidation and eicosanoid metabolism, and has been associated with increased frequency of cardiovascular events. The current study was designed to evaluate plasma lipids, susceptibility of LDL to oxidation and oxidant–antioxidant status and their relationships in patients with psoriasis. Methods: The study group included 35 patients with psoriasis (18 females and 17 males), and 35 sex- and age-matched healthy volunteers (16 females and 19 males). From blood samples, their lipids, lipoproteins, acute phase reactants, lipid peroxidation products [lipid hydroperoxide (LHP) and malondialdehyde (MDA)], antioxidant enzymes [glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT)], total antioxidant status (TAS) and autoantibodies against oxidized low-density lipoprotein (AuAb-oxLDL) levels were determined. Moreover, the susceptibility of copper-induced in vitro oxidation of LDL was examined. Results: The mean levels of atherogenic lipids (total cholesterol [TC], triacylglycerol [TG] and LDL cholesterol [LDL-C]), acute-phase reactants (CRP, ESR, PMNLs, ceruloplasmin and fibrinogen) and lipid peroxidation products, AuAb-oxLDL levels in patients with psoriasis were found to be significantly higher than those of healthy subjects. On the other hand, TAS and antioxidant enzyme activities (CAT, SOD and GSH-Px in erythrocyte and SOD in plasma) were significantly lower when compared to healthy subjects. The lag times [ t(lag)], a measure of resistance to oxidation of LDL, were also lower. The levels of AuAb-oxLDL in patients were correlated with TC, LDL-C, plasma LHP, erythrocyte MDA, oxidized LDL-MDA (oxLDL-MDA), fibrinogen, CRP, PMNL levels and plasma SOD activities ( r=0.69, P