Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice

In the present study, the inheritance of resistance and susceptibility to bladder and kidney infections in BALB/c, C3H/HeJ, F1, and backcross mice was investigated, and the number of genes contributing to the phenotypes was estimated. Infections were induced in female mice by intravesical inoculatio...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2003-02, Vol.187 (3), p.418-423
Main Authors: Hopkins, Walter J., Elkahwaji, Johny E., Heisey, Dennis M., Ott, Christopher J.
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacteriology
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Crosses, Genetic
Cystitis - genetics
Cystitis - microbiology
Escherichia coli
Escherichia coli - physiology
Escherichia coli Infections - genetics
Escherichia coli Infections - microbiology
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease - genetics
Genetics of eukaryotes. Biological and molecular evolution
Infections
Kidneys
Male
Medical genetics
Mice
Mice, Inbred C3H
Mice, Inbred Strains
Microbiology
Multifactorial Inheritance - genetics
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phenotype
Phenotypes
Phenotypic traits
Quantitative trait loci
Urinary bladder
Urinary tract infections
Urinary Tract Infections - genetics
Urinary Tract Infections - microbiology
Vertebrata
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c449t-5af04148278161e0b900f8d4088744fa7e5e4f73449dee8a778a43d1ea1966053
cites
container_end_page 423
container_issue 3
container_start_page 418
container_title The Journal of infectious diseases
container_volume 187
creator Hopkins, Walter J.
Elkahwaji, Johny E.
Heisey, Dennis M.
Ott, Christopher J.
description In the present study, the inheritance of resistance and susceptibility to bladder and kidney infections in BALB/c, C3H/HeJ, F1, and backcross mice was investigated, and the number of genes contributing to the phenotypes was estimated. Infections were induced in female mice by intravesical inoculation with Escherichia coli and the number of bacteria in bladder and kidneys was quantified at 10 days. The (BALB/c × C3H/HeJ) F1 mice had bladder and kidney infection intensities equivalent to those observed in the resistant BALB/c parents. Twelve percent of the (F1 × C3H/HeJ) backcross mice had severe bladder infections, similar to the susceptible C3H/HeJ parents. Kidney infections ranging in intensity between those observed in BALB/c and C3H/HeJ parents were present in one-half of the backcross mice. Statistical analyses indicated that ⩾1 gene is responsible for the increased susceptibility of C3H/HeJ mice and that the trait appears to be recessive
doi_str_mv 10.1086/367963
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72987283</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30085370</jstor_id><oup_id>10.1086/367963</oup_id><sourcerecordid>30085370</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-5af04148278161e0b900f8d4088744fa7e5e4f73449dee8a778a43d1ea1966053</originalsourceid><addsrcrecordid>eNqF0l1rFDEUBuBBFLut-g-UWNC7sfmaJHOpS9tZ3SJixeJNyCZnaNbZzJrMgPvvzTJLFwTxKhfn4T0c3hTFC4LfEazEBROyFuxRMSMVk6UQhD0uZhhTWhJV1yfFaUprjDHP7mlxQmhVUU6rWREW4R6iH0ywgPoWfR2The3gV77zww4NPVoEN1pw6DLZvbT33iDbdx596IxzEJEJDn3yLsAu2xbs4PuQkA_oCjamAzRnzUUDH9GNt_CseNKaLsHzw3tWfLu6vJ035fLz9WL-fllazuuhrEyLOeGKSkUEAbyqMW6V41gpyXlrJFTAW8kydgDKSKkMZ46AIbUQuGJnxdspdxv7XyOkQW98PqzrTIB-TFrSWkmq2H8hUUooLnCG53_BdT_GkI_QlLKa8KrixzQb-5QitHob_cbEnSZY73vSU08ZvjqkjasNuCM7FJPBmwMwyZqujbkgn44ur6NM1Nm9nlw_bv-97OVk1mno44NiGKv8WfanldPcpwF-P8xN_KmFZLLSzd0P_f36Zvnl9q7RnP0Bztu5xw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223914554</pqid></control><display><type>article</type><title>Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice</title><source>Oxford Journals Online</source><creator>Hopkins, Walter J. ; Elkahwaji, Johny E. ; Heisey, Dennis M. ; Ott, Christopher J.</creator><creatorcontrib>Hopkins, Walter J. ; Elkahwaji, Johny E. ; Heisey, Dennis M. ; Ott, Christopher J.</creatorcontrib><description>In the present study, the inheritance of resistance and susceptibility to bladder and kidney infections in BALB/c, C3H/HeJ, F1, and backcross mice was investigated, and the number of genes contributing to the phenotypes was estimated. Infections were induced in female mice by intravesical inoculation with Escherichia coli and the number of bacteria in bladder and kidneys was quantified at 10 days. The (BALB/c × C3H/HeJ) F1 mice had bladder and kidney infection intensities equivalent to those observed in the resistant BALB/c parents. Twelve percent of the (F1 × C3H/HeJ) backcross mice had severe bladder infections, similar to the susceptible C3H/HeJ parents. Kidney infections ranging in intensity between those observed in BALB/c and C3H/HeJ parents were present in one-half of the backcross mice. Statistical analyses indicated that ⩾1 gene is responsible for the increased susceptibility of C3H/HeJ mice and that the trait appears to be recessive</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/367963</identifier><identifier>PMID: 12552425</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Bacteria ; Bacteriology ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; Crosses, Genetic ; Cystitis - genetics ; Cystitis - microbiology ; Escherichia coli ; Escherichia coli - physiology ; Escherichia coli Infections - genetics ; Escherichia coli Infections - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease - genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Infections ; Kidneys ; Male ; Medical genetics ; Mice ; Mice, Inbred C3H ; Mice, Inbred Strains ; Microbiology ; Multifactorial Inheritance - genetics ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Phenotype ; Phenotypes ; Phenotypic traits ; Quantitative trait loci ; Urinary bladder ; Urinary tract infections ; Urinary Tract Infections - genetics ; Urinary Tract Infections - microbiology ; Vertebrata</subject><ispartof>The Journal of infectious diseases, 2003-02, Vol.187 (3), p.418-423</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Feb 1, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-5af04148278161e0b900f8d4088744fa7e5e4f73449dee8a778a43d1ea1966053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=14552369$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12552425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hopkins, Walter J.</creatorcontrib><creatorcontrib>Elkahwaji, Johny E.</creatorcontrib><creatorcontrib>Heisey, Dennis M.</creatorcontrib><creatorcontrib>Ott, Christopher J.</creatorcontrib><title>Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>In the present study, the inheritance of resistance and susceptibility to bladder and kidney infections in BALB/c, C3H/HeJ, F1, and backcross mice was investigated, and the number of genes contributing to the phenotypes was estimated. Infections were induced in female mice by intravesical inoculation with Escherichia coli and the number of bacteria in bladder and kidneys was quantified at 10 days. The (BALB/c × C3H/HeJ) F1 mice had bladder and kidney infection intensities equivalent to those observed in the resistant BALB/c parents. Twelve percent of the (F1 × C3H/HeJ) backcross mice had severe bladder infections, similar to the susceptible C3H/HeJ parents. Kidney infections ranging in intensity between those observed in BALB/c and C3H/HeJ parents were present in one-half of the backcross mice. Statistical analyses indicated that ⩾1 gene is responsible for the increased susceptibility of C3H/HeJ mice and that the trait appears to be recessive</description><subject>Animals</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Crosses, Genetic</subject><subject>Cystitis - genetics</subject><subject>Cystitis - microbiology</subject><subject>Escherichia coli</subject><subject>Escherichia coli - physiology</subject><subject>Escherichia coli Infections - genetics</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Infections</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred Strains</subject><subject>Microbiology</subject><subject>Multifactorial Inheritance - genetics</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Phenotypic traits</subject><subject>Quantitative trait loci</subject><subject>Urinary bladder</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - genetics</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Vertebrata</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0l1rFDEUBuBBFLut-g-UWNC7sfmaJHOpS9tZ3SJixeJNyCZnaNbZzJrMgPvvzTJLFwTxKhfn4T0c3hTFC4LfEazEBROyFuxRMSMVk6UQhD0uZhhTWhJV1yfFaUprjDHP7mlxQmhVUU6rWREW4R6iH0ywgPoWfR2The3gV77zww4NPVoEN1pw6DLZvbT33iDbdx596IxzEJEJDn3yLsAu2xbs4PuQkA_oCjamAzRnzUUDH9GNt_CseNKaLsHzw3tWfLu6vJ035fLz9WL-fllazuuhrEyLOeGKSkUEAbyqMW6V41gpyXlrJFTAW8kydgDKSKkMZ46AIbUQuGJnxdspdxv7XyOkQW98PqzrTIB-TFrSWkmq2H8hUUooLnCG53_BdT_GkI_QlLKa8KrixzQb-5QitHob_cbEnSZY73vSU08ZvjqkjasNuCM7FJPBmwMwyZqujbkgn44ur6NM1Nm9nlw_bv-97OVk1mno44NiGKv8WfanldPcpwF-P8xN_KmFZLLSzd0P_f36Zvnl9q7RnP0Bztu5xw</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Hopkins, Walter J.</creator><creator>Elkahwaji, Johny E.</creator><creator>Heisey, Dennis M.</creator><creator>Ott, Christopher J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice</title><author>Hopkins, Walter J. ; Elkahwaji, Johny E. ; Heisey, Dennis M. ; Ott, Christopher J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-5af04148278161e0b900f8d4088744fa7e5e4f73449dee8a778a43d1ea1966053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Crosses, Genetic</topic><topic>Cystitis - genetics</topic><topic>Cystitis - microbiology</topic><topic>Escherichia coli</topic><topic>Escherichia coli - physiology</topic><topic>Escherichia coli Infections - genetics</topic><topic>Escherichia coli Infections - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Infections</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred Strains</topic><topic>Microbiology</topic><topic>Multifactorial Inheritance - genetics</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Phenotypic traits</topic><topic>Quantitative trait loci</topic><topic>Urinary bladder</topic><topic>Urinary tract infections</topic><topic>Urinary Tract Infections - genetics</topic><topic>Urinary Tract Infections - microbiology</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hopkins, Walter J.</creatorcontrib><creatorcontrib>Elkahwaji, Johny E.</creatorcontrib><creatorcontrib>Heisey, Dennis M.</creatorcontrib><creatorcontrib>Ott, Christopher J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hopkins, Walter J.</au><au>Elkahwaji, Johny E.</au><au>Heisey, Dennis M.</au><au>Ott, Christopher J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>187</volume><issue>3</issue><spage>418</spage><epage>423</epage><pages>418-423</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>In the present study, the inheritance of resistance and susceptibility to bladder and kidney infections in BALB/c, C3H/HeJ, F1, and backcross mice was investigated, and the number of genes contributing to the phenotypes was estimated. Infections were induced in female mice by intravesical inoculation with Escherichia coli and the number of bacteria in bladder and kidneys was quantified at 10 days. The (BALB/c × C3H/HeJ) F1 mice had bladder and kidney infection intensities equivalent to those observed in the resistant BALB/c parents. Twelve percent of the (F1 × C3H/HeJ) backcross mice had severe bladder infections, similar to the susceptible C3H/HeJ parents. Kidney infections ranging in intensity between those observed in BALB/c and C3H/HeJ parents were present in one-half of the backcross mice. Statistical analyses indicated that ⩾1 gene is responsible for the increased susceptibility of C3H/HeJ mice and that the trait appears to be recessive</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12552425</pmid><doi>10.1086/367963</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0022-1899
ispartof The Journal of infectious diseases, 2003-02, Vol.187 (3), p.418-423
issn 0022-1899
1537-6613
language eng
recordid cdi_proquest_miscellaneous_72987283
source Oxford Journals Online
subjects Animals
Bacteria
Bacteriology
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Crosses, Genetic
Cystitis - genetics
Cystitis - microbiology
Escherichia coli
Escherichia coli - physiology
Escherichia coli Infections - genetics
Escherichia coli Infections - microbiology
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease - genetics
Genetics of eukaryotes. Biological and molecular evolution
Infections
Kidneys
Male
Medical genetics
Mice
Mice, Inbred C3H
Mice, Inbred Strains
Microbiology
Multifactorial Inheritance - genetics
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phenotype
Phenotypes
Phenotypic traits
Quantitative trait loci
Urinary bladder
Urinary tract infections
Urinary Tract Infections - genetics
Urinary Tract Infections - microbiology
Vertebrata
title Inheritance of Susceptibility to Induced Escherichia coli Bladder and Kidney Infections in Female C3H/HeJ Mice
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T14%3A54%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inheritance%20of%20Susceptibility%20to%20Induced%20Escherichia%20coli%20Bladder%20and%20Kidney%20Infections%20in%20Female%20C3H/HeJ%20Mice&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Hopkins,%20Walter%20J.&rft.date=2003-02-01&rft.volume=187&rft.issue=3&rft.spage=418&rft.epage=423&rft.pages=418-423&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/367963&rft_dat=%3Cjstor_proqu%3E30085370%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c449t-5af04148278161e0b900f8d4088744fa7e5e4f73449dee8a778a43d1ea1966053%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=223914554&rft_id=info:pmid/12552425&rft_jstor_id=30085370&rft_oup_id=10.1086/367963&rfr_iscdi=true