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Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression
OBJECTIVE: Neuroimaging studies reveal abnormalities of regional cerebral blood flow (rCBF) in major depression. In this study the authors prospectively investigated rCBF and clinical response to venlafaxine, a novel antidepressant. METHOD: A trial of venlafaxine was performed with seven patients re...
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| Published in: | The American journal of psychiatry 2003-02, Vol.160 (2), p.374-376 |
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| Main Authors: | , , , , |
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| container_end_page | 376 |
| container_issue | 2 |
| container_start_page | 374 |
| container_title | The American journal of psychiatry |
| container_volume | 160 |
| creator | Davies, Julia Lloyd, Keith R. Jones, Ivor K. Barnes, Anna Pilowsky, Lyn S. |
| description | OBJECTIVE: Neuroimaging studies reveal abnormalities of regional cerebral blood flow (rCBF) in major depression. In this study the authors prospectively investigated rCBF and clinical response to venlafaxine, a novel antidepressant. METHOD: A trial of venlafaxine was performed with seven patients referred with ICD-10 major depression. At entry and 6-week follow-up, the Beck Depression Inventory and Hamilton Depression Rating Scale were administered and rCBF was measured by means of single photon emission computed tomography with [99mTc]hexamethylpropyleneamine oxime. Blood flow changes were explored with statistical parametric mapping. RESULTS: The subjects showed significant improvement after treatment. Statistical parametric mapping analysis revealed increased rCBF bilaterally in the thalamus and decreased rCBF in the left occipital lobe, right cerebellum, and temporal cortex bilaterally. CONCLUSIONS: These data confirm limbic cortical rCBF changes associated with effective antidepressant treatment. |
| doi_str_mv | 10.1176/appi.ajp.160.2.374 |
| format | article |
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In this study the authors prospectively investigated rCBF and clinical response to venlafaxine, a novel antidepressant. METHOD: A trial of venlafaxine was performed with seven patients referred with ICD-10 major depression. At entry and 6-week follow-up, the Beck Depression Inventory and Hamilton Depression Rating Scale were administered and rCBF was measured by means of single photon emission computed tomography with [99mTc]hexamethylpropyleneamine oxime. Blood flow changes were explored with statistical parametric mapping. RESULTS: The subjects showed significant improvement after treatment. Statistical parametric mapping analysis revealed increased rCBF bilaterally in the thalamus and decreased rCBF in the left occipital lobe, right cerebellum, and temporal cortex bilaterally. CONCLUSIONS: These data confirm limbic cortical rCBF changes associated with effective antidepressant treatment.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.160.2.374</identifier><identifier>PMID: 12562589</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Antidepressive Agents, Second-Generation - pharmacology ; Antidepressive Agents, Second-Generation - therapeutic use ; Biological and medical sciences ; Brain ; Brain - blood supply ; Brain - diagnostic imaging ; Brain - drug effects ; Cerebral Cortex - blood supply ; Cerebral Cortex - diagnostic imaging ; Clinical trials ; Cyclohexanols - pharmacology ; Cyclohexanols - therapeutic use ; Depressive Disorder - diagnostic imaging ; Depressive Disorder - drug therapy ; Depressive Disorder - physiopathology ; Drug therapy ; Female ; Humans ; Limbic System - blood supply ; Limbic System - diagnostic imaging ; Male ; Medical sciences ; Mental depression ; Middle Aged ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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In this study the authors prospectively investigated rCBF and clinical response to venlafaxine, a novel antidepressant. METHOD: A trial of venlafaxine was performed with seven patients referred with ICD-10 major depression. At entry and 6-week follow-up, the Beck Depression Inventory and Hamilton Depression Rating Scale were administered and rCBF was measured by means of single photon emission computed tomography with [99mTc]hexamethylpropyleneamine oxime. Blood flow changes were explored with statistical parametric mapping. RESULTS: The subjects showed significant improvement after treatment. Statistical parametric mapping analysis revealed increased rCBF bilaterally in the thalamus and decreased rCBF in the left occipital lobe, right cerebellum, and temporal cortex bilaterally. CONCLUSIONS: These data confirm limbic cortical rCBF changes associated with effective antidepressant treatment.</description><subject>Adult</subject><subject>Antidepressive Agents, Second-Generation - pharmacology</subject><subject>Antidepressive Agents, Second-Generation - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - drug effects</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Clinical trials</subject><subject>Cyclohexanols - pharmacology</subject><subject>Cyclohexanols - therapeutic use</subject><subject>Depressive Disorder - diagnostic imaging</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - physiopathology</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Limbic System - blood supply</subject><subject>Limbic System - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Regional Blood Flow - drug effects</subject><subject>Technetium Tc 99m Exametazime</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Treatment Outcome</subject><subject>Venlafaxine Hydrochloride</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi0EokvLH-CALCS4JbXH8UeOsNAWqQipagsXZM1mJ92ssnGwsyr8e7zdFZU4cLItPe8744exV1KUUlpziuPYlbgeS2lECaWy1RM2k1rpwgK4p2wmhICi1ur7EXuR0jo_hbLwnB1J0Aa0q2fsx3yFwx0l3g38iu66MGDP5xRpEfPlQx_Ckp_14Z5_66YVv6WhxxZ_dQPtAtOK-HUknDY0TDy0_AuuQ-QfaYyUUu46Yc9a7BO9PJzH7Obs0_X8orj8ev55_v6yQFWbqWhIyUVrjTULBKwbATW0EpVTutXCgUInqsYZK6kWGpfS6Qq1BeUcOqKlOmbv9r1jDD-3lCa_6VJDfY8DhW3yFmpXK-Ey-OYfcB22Mf85eQBRWQNVlSHYQ00MKUVq_Ri7DcbfXgq_M-935n0277N5Dz6bz6HXh-btYkPLx8hBdQbeHgBMDfZtxKHp0iNXaVkZozJ3uucehvxd7z-j_wBn5Zwc</recordid><startdate>20030201</startdate><enddate>20030201</enddate><creator>Davies, Julia</creator><creator>Lloyd, Keith R.</creator><creator>Jones, Ivor K.</creator><creator>Barnes, Anna</creator><creator>Pilowsky, Lyn S.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20030201</creationdate><title>Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression</title><author>Davies, Julia ; Lloyd, Keith R. ; Jones, Ivor K. ; Barnes, Anna ; Pilowsky, Lyn S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a396t-ce31bf7676ba2a9c0292f1a3835f50823a804c8671e905ad1854a572388a8eed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Antidepressive Agents, Second-Generation - pharmacology</topic><topic>Antidepressive Agents, Second-Generation - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - drug effects</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Clinical trials</topic><topic>Cyclohexanols - pharmacology</topic><topic>Cyclohexanols - therapeutic use</topic><topic>Depressive Disorder - diagnostic imaging</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - physiopathology</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Limbic System - blood supply</topic><topic>Limbic System - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Regional Blood Flow - drug effects</topic><topic>Technetium Tc 99m Exametazime</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Treatment Outcome</topic><topic>Venlafaxine Hydrochloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, Julia</creatorcontrib><creatorcontrib>Lloyd, Keith R.</creatorcontrib><creatorcontrib>Jones, Ivor K.</creatorcontrib><creatorcontrib>Barnes, Anna</creatorcontrib><creatorcontrib>Pilowsky, Lyn S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, Julia</au><au>Lloyd, Keith R.</au><au>Jones, Ivor K.</au><au>Barnes, Anna</au><au>Pilowsky, Lyn S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2003-02-01</date><risdate>2003</risdate><volume>160</volume><issue>2</issue><spage>374</spage><epage>376</epage><pages>374-376</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: Neuroimaging studies reveal abnormalities of regional cerebral blood flow (rCBF) in major depression. In this study the authors prospectively investigated rCBF and clinical response to venlafaxine, a novel antidepressant. METHOD: A trial of venlafaxine was performed with seven patients referred with ICD-10 major depression. At entry and 6-week follow-up, the Beck Depression Inventory and Hamilton Depression Rating Scale were administered and rCBF was measured by means of single photon emission computed tomography with [99mTc]hexamethylpropyleneamine oxime. Blood flow changes were explored with statistical parametric mapping. RESULTS: The subjects showed significant improvement after treatment. Statistical parametric mapping analysis revealed increased rCBF bilaterally in the thalamus and decreased rCBF in the left occipital lobe, right cerebellum, and temporal cortex bilaterally. CONCLUSIONS: These data confirm limbic cortical rCBF changes associated with effective antidepressant treatment.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>12562589</pmid><doi>10.1176/appi.ajp.160.2.374</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 2003-02, Vol.160 (2), p.374-376 |
| issn | 0002-953X 1535-7228 |
| language | eng |
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| source | American Psychiatric Publishing Journals (1997-Present) |
| subjects | Adult Antidepressive Agents, Second-Generation - pharmacology Antidepressive Agents, Second-Generation - therapeutic use Biological and medical sciences Brain Brain - blood supply Brain - diagnostic imaging Brain - drug effects Cerebral Cortex - blood supply Cerebral Cortex - diagnostic imaging Clinical trials Cyclohexanols - pharmacology Cyclohexanols - therapeutic use Depressive Disorder - diagnostic imaging Depressive Disorder - drug therapy Depressive Disorder - physiopathology Drug therapy Female Humans Limbic System - blood supply Limbic System - diagnostic imaging Male Medical sciences Mental depression Middle Aged Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Regional Blood Flow - drug effects Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon Treatment Outcome Venlafaxine Hydrochloride |
| title | Changes in Regional Cerebral Blood Flow With Venlafaxine in the Treatment of Major Depression |
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