Chlamydia Trachomatis omp1 Genotypic Diversity and Concordance with Sexual Network Data

Sexual and social network analysis have been proposed as novel sexually transmitted disease control and research tools. Here, the concordance between chlamydia genotype data and a large sexual network constructed from routinely collected contact tracing data was examined. A sexual network was constr...

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Bibliographic Details
Published in:The Journal of infectious diseases 2003-01, Vol.187 (2), p.279-286
Main Authors: Cabral, Teresa, Jolly, Ann M., Wylie, John L.
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Chlamydia Infections - epidemiology
Chlamydia Infections - microbiology
Chlamydia trachomatis - genetics
Contact Tracing
Female
Genetic Variation - genetics
Genotype
Human bacterial diseases
Humans
Infectious diseases
Male
Manitoba
Medical sciences
Porins - genetics
Sexual Partners
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Summary:Sexual and social network analysis have been proposed as novel sexually transmitted disease control and research tools. Here, the concordance between chlamydia genotype data and a large sexual network constructed from routinely collected contact tracing data was examined. A sexual network was constructed for Manitoba, Canada, from province-wide contact tracing data. Positive chlamydia specimens from the same time period were collected and genotyped by omp1 DNA sequencing. A high degree of concordance was found between transmission events, on the basis of molecular data, and proposed transmission events, on the basis of sexual network data. Discordant results appeared to occur when a portion of the network contained potential core group members or in areas where contact tracing is difficult to carry out. The agreement between the molecular and epidemiologic data suggests that the use of routine contact tracing data is a valid approach for the construction of sexual networks.
ISSN:0022-1899
1537-6613
DOI:10.1086/346048