Serological response to "Rochalimaea henselae" antigen in suspected cat-scratch disease

There are no generally accepted diagnostic tests for cat-scratch disease (CSD), the cause of which is unknown. During the development of an indirect fluorescence antibody (IFA) test for detection of antibodies to " Rochalimaea henselae", sera from patients with CSD were found to have high...

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Bibliographic Details
Published in:The Lancet (British edition) 1992-06, Vol.339 (8807), p.1443-1445
Main Authors: Regnery, R.L, Olson, J.G, Perkins, B.A, Bibb, W
Format: Article
Language:English
Subjects:
Antigens, Bacterial - analysis
Biological and medical sciences
Cat-Scratch Disease - diagnosis
Cat-Scratch Disease - microbiology
Disease
Fluorescence
Fluorescent Antibody Technique
Humans
Immunological methods for diagnosis and exploration
Immunopathology
Medical research
Medical sciences
Rickettsieae - immunology
Serologic Tests
Serological tests
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Summary:There are no generally accepted diagnostic tests for cat-scratch disease (CSD), the cause of which is unknown. During the development of an indirect fluorescence antibody (IFA) test for detection of antibodies to " Rochalimaea henselae", sera from patients with CSD were found to have high titres to R henselae antigens. Further tests with this assay showed that 36 (88%) of 41 patients with suspected CSD had serum titres of 64 or more to R henselaeantigen, that there was a low prevalence (3%) of substantial titres to R henselae in healthy controls (n=107), and that the immune responses to R henselae antigens were specific. These data suggest that the R henselae IFA test, or other serological assays based on R henselae, may be useful for diagnosis of CSD.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(92)92032-B