Normal-release and controlled-release oxycodone: pharmacokinetics, pharmacodynamics, and controversy

Oxycodone has become one of the most popular opioids in the United States. It is superior to morphine in oral absorption and bioavailability, and similar in terms of protein binding and lipophilicity. Gender more than age influences oxycodone elimination. Unlike morphine, oxycodone is metabolized by...

Full description

Saved in:
Bibliographic Details
Published in:Supportive care in cancer 2003-02, Vol.11 (2), p.84-92
Main Authors: DAVIS, Mellar P, VARGA, James, DICKERSON, Duke, WALSH, Declan, LEGRAND, Susan B, LAGMAN, Ruth
Format: Article
Language:English
Subjects:
Adult
Aged
Analgesics
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - pharmacokinetics
Analgesics, Opioid - pharmacology
Biological and medical sciences
Delayed-Action Preparations
Female
Humans
Liver Failure - complications
Male
Medical sciences
Middle Aged
Morphine - administration & dosage
Morphine - pharmacokinetics
Morphine - pharmacology
Narcotics
Neoplasms - complications
Neuropharmacology
Oxycodone - administration & dosage
Oxycodone - pharmacokinetics
Oxycodone - pharmacology
Pain - drug therapy
Palliative Care
Pharmacology. Drug treatments
Sex Factors
Uremia - complications
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oxycodone has become one of the most popular opioids in the United States. It is superior to morphine in oral absorption and bioavailability, and similar in terms of protein binding and lipophilicity. Gender more than age influences oxycodone elimination. Unlike morphine, oxycodone is metabolized by the cytochrome isoenzyme CYP2D6, which is severely impaired by liver dysfunction. Controlled-release (CR) oxycodone has become one of the most frequently utilized sustained-release opioids in the United States. Both its analgesic benefits and its side effects are similar to those of CR morphine. CR oxycodone is similar to morphine and other opioids in its abuse potential. Deaths attributable to oxycodone are usually associated with polysubstance abuse in which oxycodone is combined with psychostimulants, other opioids, benzodiazepines or alcohol. Oxycodone's kappa receptor binding has little role in abuse or addiction. The cost of CR oxycodone is prohibitive for most American hospices.
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-002-0385-9