Simultaneous cardiac output and regional myocardial perfusion determination with PET and nitrogen 13 ammonia

Background. The purpose of this study was to evaluate the possibility of measuring cardiac output during positron emission tomography (PET) examination of myocardial perfusion with nitrogen 13 ammonia. Methods and Results. In 7 patients undergoing right-sided cardiac catheterization for evaluation o...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2003-01, Vol.10 (1), p.28-33
Main Authors: Hove, Jens D., Kofoed, Klaus F., Wu, Hsiao M., Holm, Søren, Friberg, Lars, Meyer, Christian, Aldershvile, Jan, Hesse, Birger, Kelbæk, Henning
Format: Article
Language:English
Subjects:
Adult
Aged
Ammonia
Cardiac Catheterization
Cardiac Output - physiology
Coronary Circulation - physiology
Heart failure
Heart Failure - diagnostic imaging
Heart Failure - physiopathology
Heart Failure - surgery
Heart Transplantation
Humans
Linear Models
Male
Middle Aged
Nitrogen Radioisotopes
Observer Variation
Reproducibility of Results
Thermodilution - methods
Tomography, Emission-Computed
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Summary:Background. The purpose of this study was to evaluate the possibility of measuring cardiac output during positron emission tomography (PET) examination of myocardial perfusion with nitrogen 13 ammonia. Methods and Results. In 7 patients undergoing right-sided cardiac catheterization for evaluation of heart failure and 6 patients who had undergone heart transplantation, a thermodilution catheter for continuous measurement of cardiac output was inserted. An N-13 ammonia scan of the heart was subsequently performed, and with use of factor analysis, the time-activity curve from the right ventricle was derived from the dynamic image sequence. The PET-derived cardiac output was subsequently obtained according to the Stewart-Hamilton principle as the amount of injected tracer divided by the area under the time-activity curve. PET-acquired cardiac output measurements correlated closely with the invasively determined values for a wide range of cardiac output values (P < .0001). The mean difference was 0.12 L/min, with an SD of 0.74 L/min. The interobserver variation was low, with a mean difference of 0.06 L/min and an SD of 0.46 L/min. Conclusions. Cardiac output determination with N-13 ammonia and PET appears to be both accurate and precise and can be performed simultaneously with measurement of myocardial perfusion. (J Nucl Cardiol 2003;10:28-33)
ISSN:1071-3581
1532-6551
DOI:10.1067/mnc.2003.30