Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age

In the present study, we have assayed the enzymatic activity of Cu,Zn-SOD, Mn-SOD, GSH-Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with ag...

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Published in:Neurochemical research 1992-06, Vol.17 (6), p.599-604
Main Authors: CASTORINA, C, CAMPISI, A, DI GIACOMO, C, SORRENTI, V, RUSSO, A, VANELLA, A
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Biological and medical sciences
Catalase - metabolism
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Glucosephosphate Dehydrogenase - metabolism
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Lipid Peroxidation - physiology
Male
Malondialdehyde - metabolism
Rats
Rats, Inbred Strains
Retina - enzymology
Retina - metabolism
Superoxide Dismutase - metabolism
Vertebrates: nervous system and sense organs
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Summary:In the present study, we have assayed the enzymatic activity of Cu,Zn-SOD, Mn-SOD, GSH-Px, GSH-Red, Cat, and G6PD in rat retina as a function of age. Conjugated diene levels and MDA formation were also determined. The conjugated diene levels in rat retina were found to increase significantly with age, accompanied by a marked decrease in GSH-Px and Cat activities. No age-related change in MDA levels and in GSH-Red and G6PD activity was found, whereas a significant increase in SOD activity was observed between 1 and 4 months. Decreased GSH-Px and Cat activity is related to increased lipid peroxidation with age.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00968789