Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer

Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. We used a case-control study design (162 cases and 302 controls) to test the association between three amino...

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Bibliographic Details
Published in:Cancer letters 2003-02, Vol.190 (2), p.183-190
Main Authors: Smith, Tasha R., Miller, Mark Steven, Lohman, Kurt, Lange, Ethan M., Case, L.Douglas, Mohrenweiser, Harvey W., Hu, Jennifer J.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Biological and medical sciences
Breast Cancer
Breast Neoplasms - genetics
Confidence intervals
Deoxyribonucleic acid
DNA
DNA repair
DNA repair polymorphisms
DNA-Binding Proteins - genetics
Enzymes
Female
Gene Frequency
Genes
Genetic Predisposition to Disease - genetics
Genetic susceptibility
Genotype & phenotype
Haplotypes
Humans
Medical sciences
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic - genetics
Risk factors
Statistical analysis
X-ray Repair Cross Complementing Protein 1
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Summary:Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk. We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes ( XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast cancer susceptibility. We found a weak association between the XRCC1 194Trp allele and breast cancer risk (adjusted odds ratio (OR)=1.98; 95% confidence interval (CI)=0.85–4.63). We also found a potential gene-gene interaction between the XRCC1 194Trp allele and XRCC3 241Met allele and breast cancer risk (adjusted OR=8.74; 95% CI=1.13–67.53). Although larger studies are needed to validate the study results, our data suggest that amino acid substitution variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(02)00595-5