Adrenergic contribution during acclimatization to high altitude: perspectives from Pikes Peak

We have examined the sympathoadrenal responses to both acute and chronic high-altitude exposure at the summit of Pikes Peak, CO, in both men and women. A dissociation between the adrenal medullary response (acute) with that of the sympathetic nervous system (chronic) is observed. Both alpha- and bet...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2003-01, Vol.31 (1), p.13-18
Main Authors: Mazzeo, Robert S, Reeves, John T
Format: Article
Language:English
Subjects:
Acclimatization - physiology
Altitude
Energy Metabolism
Epinephrine - blood
Exercise - physiology
Female
Humans
Lactates - metabolism
Male
Norepinephrine - blood
Oxygen Consumption - physiology
Pituitary-Adrenal System - physiology
Sensitivity and Specificity
Time Factors
Vascular Resistance - physiology
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Summary:We have examined the sympathoadrenal responses to both acute and chronic high-altitude exposure at the summit of Pikes Peak, CO, in both men and women. A dissociation between the adrenal medullary response (acute) with that of the sympathetic nervous system (chronic) is observed. Both alpha- and beta-adrenergic contributions to key metabolic and physiologic adjustments to high-altitude exposure are evident.
ISSN:0091-6331
DOI:10.1097/00003677-200301000-00004