Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxicity on multidrug resistant and sensitive leukemia cell lines

Plants are known as important source in the search for new anti-cancer agents. Cytotoxicity-guided fractionation of leaves and fruits from Licania tomentosa Bench and leaves from Chrysobalanus icaco L. resulted in the isolation of betulinic, oleanolic and pomolic acids. These triterpenoids inhibited...

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Bibliographic Details
Published in:Cancer letters 2003-02, Vol.190 (2), p.165-169
Main Authors: Fernandes, Janaina, Castilho, Rachel Oliveira, da Costa, Mariana Rangel, Wagner-Souza, Karen, Coelho Kaplan, Maria Auxiliadora, Gattass, Cerli Rocha
Format: Article
Language:English
Subjects:
Acids
Apoptosis
Apoptosis - drug effects
Bioassays
Biological and medical sciences
Cancer
Cancer therapies
Cell culture
Cell cycle
Cell Division - drug effects
Cell growth
Chrysobalanaceae
Chrysobalanus icaco
Cytotoxicity
Drug Resistance, Neoplasm
Humans
K562 Cells
Leukemia
Leukemia - pathology
Licania tomentosa
Medical sciences
Multidrug resistance
Natural products
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rosales - chemistry
Triterpenes
Triterpenes - isolation & purification
Triterpenes - pharmacology
Tumor Cells, Cultured
Tumors
Vincristine - pharmacology
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Summary:Plants are known as important source in the search for new anti-cancer agents. Cytotoxicity-guided fractionation of leaves and fruits from Licania tomentosa Bench and leaves from Chrysobalanus icaco L. resulted in the isolation of betulinic, oleanolic and pomolic acids. These triterpenoids inhibited the growth and induced apoptosis of K562, an erythroleukemia cell line. Most importantly, they also inhibited the proliferation of Lucena 1, a vincristine-resistant derivative of K562 that displays several multidrug resistance (MDR) characteristics. Taken together, our findings emphasize the anti-tumor activity of these triterpenes on leukemia cell lines and call attention to their potential as anti MDR agents.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(02)00593-1