Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy

For treatment of early breast cancer in older women, little evidence is available from randomised trials. We conducted a randomised trial comparing modified radical mastectomy (MRM) with tamoxifen (TAM) as the sole initial therapy in 164 patients aged ⩾70 years with operable breast cancer. 82 were t...

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Bibliographic Details
Published in:European journal of cancer (1990) 2003-02, Vol.39 (3), p.309-316
Main Authors: Fentiman, I.S, Christiaens, M.-R, Paridaens, R, Van Geel, A, Rutgers, E, Berner, J, de Keizer, G, Wildiers, J, Nagadowska, M, Legrand, C, Therasse, P
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antineoplastic Agents, Hormonal - therapeutic use
Biological and medical sciences
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - surgery
Combined Modality Therapy - methods
Disease Progression
Elderly
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Mastectomy
Mastectomy, Radical
Medical sciences
Multivariate Analysis
Neoplasm Recurrence, Local - etiology
Prospective Studies
Randomised trial
Salvage Therapy
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Survival Analysis
Tamoxifen
Tamoxifen - therapeutic use
Treatment Outcome
Tumors
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Summary:For treatment of early breast cancer in older women, little evidence is available from randomised trials. We conducted a randomised trial comparing modified radical mastectomy (MRM) with tamoxifen (TAM) as the sole initial therapy in 164 patients aged ⩾70 years with operable breast cancer. 82 were treated by MRM and 82 with TAM. Survival curves were estimated using the Kaplan–Meier method: multivariate analyses were performed using the Cox's proportional hazards model. Endpoints included survival, time to first relapse or progression, loco-regional progression, time to distant progression and progression-free survival. After a median follow-up of approximately 10 years, there was a significantly decreased time to progression in the TAM only group (logrank P
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(02)00673-1