A Longer Duration of Neo-Adjuvant Combined Androgen Blockade Prior to Radical Prostatectomy May Lead to Lower Tumour Volume of Localised Prostate Cancer

• Published in: European urology 2003-02, Vol.43 (2), p.119-123
• Main Authors: Lorente, J.A, Arango, O, Bielsa, O, Cortadellas, R, Lloreta-Trull, J, Gelabert-Mas, A
• Format: Article
• Language: English
• Subjects: Androgen Antagonists - administration & dosage; Anilides - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Chemotherapy, Adjuvant; Chi-Square Distribution; Combined androgen blockade; Humans; Leuprolide - administration & dosage; Logistic Models; Male; Medical sciences; Neo-adjuvant therapy; Nephrology. Urinary tract diseases; Nitriles; Prostate cancer; Prostatectomy; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Retrospective Studies; Statistics, Nonparametric; Time Factors; Tosyl Compounds; Treatment Outcome; Tumors of the urinary system; Tumour volume; Urinary tract. Prostate gland
• ISSN: 0302-2838; 1873-7560
• DOI: 10.1016/S0302-2838(02)00583-3

Objectives: To analyse tumour volume (TV) in clinically localised prostate cancer patients treated with neo-adjuvant combined androgen blockade (CAB) therapy prior to radical prostatectomy. Patients and Methods: Two hundred consecutive patients treated between 1996 and 2000 were retrospectively analysed. Fifty patients underwent radical prostatectomy alone and 45 were treated with CAB for 1–3 months, 83 for 4–6 months and 22 for more than 6 months before surgery. Logistic regression analysis was performed to identify the strongest independent prognosticator of organ-confined disease. Results: No evidence of residual cancer was found in 11 specimens (5.6%). Regarding TV, 20 specimens showed less than 0.1 cc, 33 between 0.1 and 0.49 cc and 86 more than 0.5 cc. Smaller TV was found in CAB-treated patients. Significant correlation was observed between treatment duration and TV. In logistic regression analysis, only CAB duration and TV were significantly correlated with organ-confined disease. Conclusions: Prominent regressive features and lower TV were found after neo-adjuvant CAB. It seems that more prolonged treatment may lead to greater tumoural regression. Only tumour burden and length of CAB therapy were independent variables significantly correlated with pathologically localised prostate cancer.