Detection of Recurrent Colon Cancer with In-111 Labeled MoAb B72.3 in a Patient with Normal CEA and TAG-72 Levels

The usefulness of radioimmunoscintigraphy with In-111 labeled MoAb B72.3 is illustrated in this case report of a patient with an aggressive cancer of the ascending colon. When used in conjunction with CT, ultrasound examination, and MRI, radioimmunoscintigraphy improved the specificity of these othe...

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Bibliographic Details
Published in:Clinical nuclear medicine 1992-03, Vol.17 (3), p.180-184
Main Authors: VIJAYAKUMAR, VANI, BLEND, MICHAEL J, JOHNSON, DAVID, SCHNOBRICH, KAREN, GOLICK, JAN
Format: Article
Language:English
Subjects:
Adult
Antigens, Neoplasm - analysis
Carcinoembryonic Antigen - analysis
Colonic Neoplasms - diagnostic imaging
Female
Glycoproteins - analysis
Humans
Indium Radioisotopes
Neoplasm Recurrence, Local - diagnostic imaging
Radioimmunodetection
Reference Values
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Summary:The usefulness of radioimmunoscintigraphy with In-111 labeled MoAb B72.3 is illustrated in this case report of a patient with an aggressive cancer of the ascending colon. When used in conjunction with CT, ultrasound examination, and MRI, radioimmunoscintigraphy improved the specificity of these other imaging modalities, although the patientʼs serum CEA and TAG-72 levels remained within the normal ranges. In addition, MoAb imaging demonstrated superiority over CT in identifying an additional unsuspected lesion. Detection of occult disease by imaging modalities with or without elevated serum CEA levels is discussed.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199203000-00005