Expression of mBRI2 in mice

Mutations in the BRI(2) gene cause the autosomal dominant neurodegenerative diseases familial British dementia (FBD) and familial Danish dementia (FDD). BRI(2) is a member of a family of type 2 integral transmembrane spanning proteins, including mBRI(2), its murine homologue. The function of BRI(2)...

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Bibliographic Details
Published in:Neuroscience letters 2003-02, Vol.338 (2), p.95-98
Main Authors: PICKFORD, Fiona, ONSTEAD, Luisa, CAMACHO-PRIHAR, Carolina, HARDY, John, MCGOWAN, Eileen
Format: Article
Language:English
Subjects:
Amyloid - genetics
Amyloid - metabolism
Animals
Biological and medical sciences
Blotting, Northern
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
In Situ Hybridization
Medical sciences
Membrane Glycoproteins
Membrane Proteins
Mice
Neurology
Organ Specificity
RNA, Messenger - metabolism
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Summary:Mutations in the BRI(2) gene cause the autosomal dominant neurodegenerative diseases familial British dementia (FBD) and familial Danish dementia (FDD). BRI(2) is a member of a family of type 2 integral transmembrane spanning proteins, including mBRI(2), its murine homologue. The function of BRI(2) is unknown. Northern and Western analyses and in situ hybridization were employed to determine the expression of mBRI(2) in the mouse. mBRI(2) mRNA was expressed in several tissues including the liver, heart, lung, and ubiquitously throughout the brain. mBRI(2) protein was detected at high levels in many brain regions. Murine BRI(2) expression is similar to that described in the human brain but does not fully explain the distribution of pathology seen in FBD and FDD.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)01356-3