Hypothalamic co-localization of substance P receptor and transneuronal tracer from the lordosis-relevant lumbar epaxial muscles in the female rat

Previous studies indicated that within the ventromedial hypothalamus (VMH), the estrogen receptor α (ERα)-containing neurons express substance P (SP), but do not comprise the majority of projection neurons. The present study tested the hypothesis that projection neurons within the VMH express SP rec...

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Bibliographic Details
Published in:Neuroscience letters 2003-02, Vol.338 (2), p.111-114
Main Authors: Daniels, Derek, Miselis, Richard R., Flanagan-Cato, Loretta M.
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animals
Behavioral psychophysiology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Herpesvirus 1, Suid
Hypothalamus - metabolism
Hypothalamus - virology
Immunohistochemistry
Lordosis
Muscle, Skeletal - virology
Neurons - metabolism
Neurons - virology
NK1
Pseudorabies virus
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Receptors, Neurokinin-1 - metabolism
Reproductive behavior
Spine
Substance P
Tract tracing
Ventromedial Hypothalamic Nucleus - metabolism
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Summary:Previous studies indicated that within the ventromedial hypothalamus (VMH), the estrogen receptor α (ERα)-containing neurons express substance P (SP), but do not comprise the majority of projection neurons. The present study tested the hypothesis that projection neurons within the VMH express SP receptors (NK1), allowing responsiveness to signals from ERα-containing neurons. Pseudorabies virus was transneuronally transported from the lordosis-relevant lumbar epaxial muscles to the VMH, labeling 28% of the NK1-containing neurons in the VMH and surrounding area. Thus, SP may influence sexual behavior through its release from the ERα-containing neurons, perhaps synaptically affecting NK1 receptor-labeled lordosis-relevant projection neurons within the VMH.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)01368-X