In-vitro activity of sparfloxacin, pefloxacin, ciprofloxacin and temafloxacin against clinical isolates of Acinetobacter spp

Nosocomial infections with Acinetobacter spp. constitute a difficult therapeutic problem due to a rapid increase in resistance to most newer beta -lactams and aminoglycosides. Sparfloxacin was the most active fluorinated quinolone against these clinical isolates of Acinetobacter spp. with a MIC sub(...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1992-04, Vol.29 (4), p.466-468
Main Authors: JOLY-GUILLOU, M. L., BERGOGNE-BÉRÉZIN, E.
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter - drug effects
Anti-Infective Agents - pharmacology
Ciprofloxacin - pharmacology
Fluoroquinolones
Pefloxacin - pharmacology
Quinolones - pharmacology
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Summary:Nosocomial infections with Acinetobacter spp. constitute a difficult therapeutic problem due to a rapid increase in resistance to most newer beta -lactams and aminoglycosides. Sparfloxacin was the most active fluorinated quinolone against these clinical isolates of Acinetobacter spp. with a MIC sub(50) of 3 mg/L and a geometric mean MIC of 1 multiplied by 6 mg/L. The proportions of fully susceptible strains were 25%, 30%, 31% and 45% for pefloxacin, ciprofloxacin, temafloxacin and sparfloxacin respectively. The Figure shows the killing curves after exposure to antibiotics. A bactericidal effect was obtained within 3 h with sparfloxacin and 5 h with temafloxacin; ciprofloxacin and pefloxacin were bacteriostatic only.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/29.4.466