Neuroendocrine and behavioral effects of high-dose anabolic steroid administration in male normal volunteers

Objective: Despite widespread abuse of anabolic-androgenic steroids (AAS), the endocrine effects of supraphysiologic doses of these compounds remain unclear. We administered the AAS methyltestosterone (MT) to 20 normal volunteers in an in-patient setting, examined its effects on levels of pituitary-...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2003-04, Vol.28 (3), p.317-331
Main Authors: Daly, R.C., Su, T.-P., Schmidt, P.J., Pagliaro, M., Pickar, D., Rubinow, D.R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Affect - drug effects
Aggression
Aggression - drug effects
Anabolic Agents - pharmacology
Anabolic steroids
Analysis of Variance
Androgens - metabolism
Behavioral psychophysiology
Biological and medical sciences
Dose-Response Relationship, Drug
Estrogens - metabolism
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Humans
Hypothalamo-Hypophyseal System - drug effects
Male
Methyltestosterone
Methyltestosterone - pharmacology
Mood
Neurosecretory Systems - drug effects
Pituitary-Adrenal System - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reference Values
Sex Hormone-Binding Globulin - drug effects
Thyroid
Thyroid Function Tests
Thyroid Hormones - metabolism
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Summary:Objective: Despite widespread abuse of anabolic-androgenic steroids (AAS), the endocrine effects of supraphysiologic doses of these compounds remain unclear. We administered the AAS methyltestosterone (MT) to 20 normal volunteers in an in-patient setting, examined its effects on levels of pituitary-gonadal, -thyroid, and -adrenal hormones, and examined potential relationships between endocrine changes and MT-induced psychological symptoms. Method: Subjects received MT (three days of 40 mg/day, then three days of 240 mg/day) or placebo in a fixed sequence with neither subjects nor raters aware of order. Samples were obtained at the ends of the baseline, high-dose MT and withdrawal phases. Potential relationships between hormonal changes and visual analog scale measured mood changes were examined. Results: Significant decreases in plasma levels of gonadotropins, gonadal steroids, sex hormone binding globulin, free T3 and T4, and thyroid binding globulin (Bonferroni t, p
ISSN:0306-4530
1873-3360
DOI:10.1016/S0306-4530(02)00025-2