A measles virus isolate from a child with Kawasaki disease: sequence comparison with contemporaneous isolates from 'classical' cases

1 Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB and 2 Institute of Child Health, London, U.K. We examined the relationship between a measles virus isolate from a child with Kawasaki disease and two contemporaneous wild-type isolates from children with ‘cl...

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Bibliographic Details
Published in:Journal of general virology 1992-06, Vol.73 (6), p.1581-1586
Main Authors: Schulz, Thomas F, Hoad, Julian G, Whitby, Denise, Tizard, E. Jane, Dillon, Michael J, Weiss, Robin A
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Biological and medical sciences
Child
Child, Preschool
DNA, Viral
Genetic Variation
HeLa Cells
Humans
Infant
Measles - microbiology
Measles Vaccine - genetics
measles virus
Measles virus - genetics
Measles virus - isolation & purification
Medical sciences
Molecular Sequence Data
Mucocutaneous Lymph Node Syndrome - microbiology
Polymerase Chain Reaction
RNA, Viral
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sequence Homology, Nucleic Acid
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Summary:1 Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB and 2 Institute of Child Health, London, U.K. We examined the relationship between a measles virus isolate from a child with Kawasaki disease and two contemporaneous wild-type isolates from children with ‘classical’ measles and the Schwarz vaccine strain. Sequence analysis of 3118 bp from the nucleoprotein, matrix, fusion and haemagglutinin genes of each virus revealed that the isolate from the child with Kawasaki disease was not related to measles vaccine strains and did not contain any of the marked abnormalities previously found in subacute sclerosing panencephalitis isolates, but was more akin to wild-type isolates currently circulating in the U.K. A comparison of our sequences with those obtained from earlier wild-type U.K. isolates suggests significant evolution of measles virus in the U.K. over the last decade. Received 3 December 1991; accepted 5 February 1992.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-73-6-1581