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Prevalence of T cell receptor ζchain deficiency in systemic lupus erythematosus
T cells from patients with systemic lupus erythematosus (SLE) display antigen receptor-mediated signaling aberrations associated with defective T cell receptor (TCR) z chain expression. We determined the prevalence of TCR z chain deficiency in SLE from a large cohort of unselected racially diverse p...
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Published in: | Lupus 2003-01, Vol.12 (1), p.46-51 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | T cells from patients with systemic lupus erythematosus (SLE) display antigen receptor-mediated signaling aberrations associated with defective T cell receptor (TCR) z chain expression. We determined the prevalence of TCR z chain deficiency in SLE from a large cohort of unselected racially diverse patients with different levels of clinical disease activity as determined by SLE Disease Activity Index (SLEDAI). Our data show that the occurrence of TCR z chain deficiency is 78% in SLE patients. There was no relationship between the deficiency of TCR z chain and the SLEDAI scores or therapy. TCR z chain deficiency was also not associated with age, race or gender and persisted over a 3 year follow-up period. Thus, there is a high prevalence of TCR z chain deficiency in SLE patients that is independent of disease activity, and persists over time indicating an important role for TCR z chain deficiency in SLE pathogenesis. |
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ISSN: | 0961-2033 1477-0962 |
DOI: | 10.1191/0961203303lu281oa |