Expansion of CD8+ T cells that express low levels of the B cell‐specific molecule CD20 in patients with multiple myeloma

An expanded cytotoxic/memory T‐cell subpopulation expressing low levels of the B‐cell‐specific CD20 molecule was found in peripheral blood and bone marrow of patients with multiple myeloma at the time of diagnosis, but returned to normal levels following treatment. CD3+CD20dim cells were also increa...

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Bibliographic Details
Published in:British journal of haematology 2003-02, Vol.120 (3), p.478-481
Main Authors: Katopodis, Ourania, Liossis, Stamatis‐Nick, Viglis, Vassilios, Pouli, Anastasia, Dimopoulos, Meletios‐Athanasios, Sfikakis, Petros P.
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD20 - metabolism
Biological and medical sciences
Bone Marrow - immunology
CD20
CD8-Positive T-Lymphocytes - immunology
Follow-Up Studies
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunopathology
Immunophenotyping
Medical sciences
Middle Aged
monoclonal gammopathy of unknown significance
multiple myeloma
Multiple Myeloma - immunology
Multiple Myeloma - therapy
Paraproteinemias - immunology
Prospective Studies
T-Lymphocyte Subsets - immunology
T‐cell immunophenotype
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Summary:An expanded cytotoxic/memory T‐cell subpopulation expressing low levels of the B‐cell‐specific CD20 molecule was found in peripheral blood and bone marrow of patients with multiple myeloma at the time of diagnosis, but returned to normal levels following treatment. CD3+CD20dim cells were also increased in monoclonal gammopathy of unknown significance albeit at lower levels. Lower CD3+CD20dim cell numbers at baseline may be associated with lack of response to treatment and a poor outcome. Because expansion of these T cells may be related to disease status, further studies should investigate their potentially unique function in plasma cell dyscrasias.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2003.04087.x