Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1

One-hundred and fifty-seven vertically infected HIV-1 positive infants (85 males, 72 females) underwent longitudinal assessment to determine whether early neurodevelopmental markers are useful predictors of mortality in those infants who survive to at least 4 months of age. Survival analysis methods...

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Bibliographic Details
Published in:Developmental medicine and child neurology 2003-02, Vol.45 (2), p.76-84
Main Authors: Llorente, Antolin, Brouwers, Pim, Charurat, Manhattan, Magder, Laurence, Malee, Kathleen, Mellins, Claude, Ware, Janice, Hittleman, Joan, Mofenson, Lynne, Velez-Borras, Jesus, Adeniyi-Jones, Samuel
Format: Article
Language:English
Subjects:
Age Factors
Analysis of Variance
CD4 Lymphocyte Count
Child Health
Developmental Disabilities - classification
Developmental Disabilities - diagnosis
Developmental Disabilities - virology
Disease Progression
Female
Follow-Up Studies
Gestational Age
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - mortality
HIV Infections - transmission
HIV-1
Humans
Infant
Infant Mortality
Infectious Disease Transmission, Vertical
Longitudinal Studies
Male
Original Articles
Predictive Value of Tests
Proportional Hazards Models
Risk Factors
Severity of Illness Index
Standardized Tests
Survival Analysis
Viral Load
Young Children
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Summary:One-hundred and fifty-seven vertically infected HIV-1 positive infants (85 males, 72 females) underwent longitudinal assessment to determine whether early neurodevelopmental markers are useful predictors of mortality in those infants who survive to at least 4 months of age. Survival analysis methods were used to estimate time to death for quartiles of 4-month scores (baseline) on the Bayley Scales of Infant Development (BSID). Cox proportional hazards progression was used to estimate relative hazard (RH, 95% CI) of death for BSID scores and potential confounders. Thirty infants with BSID scores at 4 months of age died during follow-up. Survival analysis revealed greater mortality rates in infants with BSID (Mental Developmental Index and Psychomotor Developmental Index) scores in the lower quartile(p=0.004, p=0.036). Unadjusted univariate analyses revealed increased mortality associated with baseline CD4+ 29%, gestational age
ISSN:0012-1622
1469-8749
DOI:10.1017/S0012162203000161