CLINICAL STUDY OF PANIPENEM/BETAMIPRON FOR BURN INFECTIONS IN THE DOMAIN OF PLASTIC AND RECONSTRUCTIVE SURGERY

The effectiveness and the safety of panipenem/betamipron, new antibiotics of the carbapenems for burn infections, were studied and the following results were obtained: 1. The preparation, 0.5g/0.5g, was administered by intravenous drip infusion twice a day to 11 cases of patients with burn infection...

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Published in:Japanese journal of antibiotics 1992/02/25, Vol.45(2), pp.181-187
Main Authors: YOSHIDA, TETSUNORI, NARUMI, EIJI, MURAZUMI, MASAHIKO, KAMO, RIEI, OHURA, TAKEHIKO, SAKAMURA, RITSUO, IIDA, KAZUNORI, HONDA, KOICHI, YAMAMOTO, YUHEI, KIMURA, CHU, IWAO, FUMIYA, SEKIDO, MITSURU
Format: Article
Language:Japanese
Subjects:
Adolescent
Aged
Aged, 80 and over
beta-Alanine - analogs & derivatives
beta-Alanine - pharmacokinetics
beta-Alanine - therapeutic use
Burns - complications
Burns - metabolism
Burns - surgery
Child
Drug Evaluation
Drug Therapy, Combination - pharmacokinetics
Drug Therapy, Combination - therapeutic use
Female
Humans
Male
Middle Aged
Skin Diseases, Infectious - drug therapy
Skin Diseases, Infectious - etiology
Skin Diseases, Infectious - metabolism
Surgery, Plastic
Thienamycins - pharmacokinetics
Thienamycins - therapeutic use
Tissue Distribution
Wound Infection - drug therapy
Wound Infection - etiology
Wound Infection - metabolism
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Summary:The effectiveness and the safety of panipenem/betamipron, new antibiotics of the carbapenems for burn infections, were studied and the following results were obtained: 1. The preparation, 0.5g/0.5g, was administered by intravenous drip infusion twice a day to 11 cases of patients with burn infections. In 10 cases for which clinical effects were evaluable, results were rated as “excellent” in 2 cases, “good” in 2 cases and “fair” in 6 cases, with an efficacy rate of 40%. 2. Penetration to the affected tissue was studied in 2 cases. The tissue level of panipenem was 0.20μg/g immediately after the end of drip infusion and 6.86μg/g 60 minutes thereafter. 3. As for the safety, a slight increase in GOT, GPT and Al-P was noted in 1 case; a slight increase in GPT, NAG and β2MG was found in 1 case; and a slight increase in GOT, GPT, Al-P and LAP was noted in 1 case, as abnormal variations in laboratory test results.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.45.181