Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas

Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non‐anaplastic, fou...

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Bibliographic Details
Published in:Pathology international 2003-02, Vol.53 (2), p.67-73
Main Authors: Son, Eun-Ik, Kim, Il-Man, Kim, Dong-Won, Yim, Man Bin, Kang, Yu-Na, Lee, Sang-Sook, Kwon, Kun-Young, Suh, Seong-Il, Kwon, Taeg-Kyu, Lee, Jung-Jeung, Kim, Dong-Sug, Kim, Sang-Pyo
Format: Article
Language:English
Subjects:
Adolescent
anaplasia
Biomarkers, Tumor - metabolism
Cerebellar Neoplasms - classification
Cerebellar Neoplasms - metabolism
Cerebellar Neoplasms - pathology
Child
Child, Preschool
Female
histopathology
Humans
Immunoenzyme Techniques
immunohistochemistry
Male
medulloblastoma
Medulloblastoma - classification
Medulloblastoma - metabolism
Medulloblastoma - pathology
Neoplasm Proteins - metabolism
pediatric
subtype
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Summary:Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non‐anaplastic, four diffuse/anaplastic, three nodular/non‐anaplastic and one nodular/anaplastic subtypes, were studied. In the present report, we investigate the expression of neural cell adhesion molecule (NCAM), nerve growth factor receptor (NGFR), neurofilament (NF), synaptophysin (SYN), glial fibrillary acidic protein (GFAP), S100, Bcl‐2, and Ki‐67 by using the immunohistochemistry against specific antibodies. This study showed that NGFR, NF, GFAP and S100 were not detected in anaplastic subtypes of medulloblastomas (0/5), while non‐anaplastic subtypes were mainly expressed within the nodules. All 17 tumors were reactive for NCAM, SYN and Bcl‐2. In addition, Ki‐67 labeling indices for anaplastic subtypes (39.0 ± 7.42%) were significantly higher than that of non‐anaplastic medulloblastomas (11.4 ± 8.04%; P 
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2003.01444.x