Aortic valve sclerosis is associated with systemic endothelial dysfunction

We sought to examine the association between aortic valve sclerosis (AVS) and systemic endothelial manifestations of the atherosclerotic process. Clinical and experimental studies suggest that AVS is a manifestation of the atherosclerotic process. Systemic endothelial dysfunction is an early sign of...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2003, Vol.41 (1), p.136-141
Main Authors: POGGIANTI, Elisa, VENNERI, Lucia, CHUBUCHNY, Vlad, JAMBRIK, Zoltan, BARONCINI, Liz Andrea, PICANO, Eugenio
Format: Article
Language:English
Subjects:
Aged
Aortic Valve - pathology
Aortic Valve Insufficiency - complications
Aortic Valve Insufficiency - diagnosis
Aortic Valve Insufficiency - physiopathology
Arteriosclerosis - complications
Biological and medical sciences
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Cardiology. Vascular system
Coronary Angiography
Coronary Artery Disease - complications
Dilatation, Pathologic
Echocardiography
Echocardiography, Stress
Endocardial and cardiac valvular diseases
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Female
Heart
Heart Valve Diseases - complications
Heart Valve Diseases - diagnosis
Heart Valve Diseases - pathology
Humans
Male
Medical sciences
Middle Aged
Risk Factors
Sclerosis
Ultrasonography
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Description
Summary:We sought to examine the association between aortic valve sclerosis (AVS) and systemic endothelial manifestations of the atherosclerotic process. Clinical and experimental studies suggest that AVS is a manifestation of the atherosclerotic process. Systemic endothelial dysfunction is an early sign of the atherosclerotic process and can be assessed by ultrasonography of the brachial artery. A total of 102 in-hospital patients (76 men; mean age 63.5 +/- 9.7 years) referred to the stress echocardiography laboratory underwent: 1) transthoracic echocardiography, with specific assessment of AVS (thickened valve leaflets with a transaortic flow velocity
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(02)02622-0