Chromosome Cohesion and Separation: From Men and Molecules

Sister chromatid cohesion and separation are fundamental for accurate genome inheritance over cell generations. Work over recent years has established the existence of a chromosomal protein complex, cohesin, that connects sister chromatids from the time they are generated in S phase onwards, and whi...

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Bibliographic Details
Published in:Current Biology 2003-02, Vol.13 (3), p.R104-R114
Main Author: Uhlmann, Frank
Format: Article
Language:English
Subjects:
Animals
Cell Cycle - physiology
Cell Cycle Proteins - metabolism
Chromatids - genetics
Chromatids - metabolism
Chromosomal Proteins, Non-Histone
Cohesins
Endopeptidases - metabolism
Fungal Proteins - metabolism
Humans
Meiosis - physiology
Models, Genetic
Nuclear Proteins - metabolism
Separase
Spindle Apparatus - metabolism
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Summary:Sister chromatid cohesion and separation are fundamental for accurate genome inheritance over cell generations. Work over recent years has established the existence of a chromosomal protein complex, cohesin, that connects sister chromatids from the time they are generated in S phase onwards, and which is destroyed at the onset of anaphase through cleavage by the protease separase. Over the last year, the function of cohesin has been investigated in higher eukaryotes, including humans, with results that have uncovered important new aspects of this process. The first structural views of cohesin have become available, and significant steps been made towards a mechanistic understanding of chromosome cohesion. Studies on separase have revealed new levels of regulation of chromosome segregation.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(03)00039-3