Activity of matrix metalloproteinases-2 and -9 in advanced laryngeal cancer

Objectives: Matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) are proteolytic enzymes that digest collagen type IV and other components of the basement membrane. They play a key role in local invasion and the formation of distant metastases by malignant tumors. The aim of this study was to evalua...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2003, Vol.128 (1), p.132-136
Main Authors: Bogusiewicz, Michal, Stryjecka-Zimmer, Marta, Szymanski, Marcin, Rechberger, Tomasz, Golabek, Wieslaw
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - analysis
Biopsy, Needle
Case-Control Studies
Cohort Studies
Culture Techniques
Female
Humans
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - surgery
Male
Matrix Metalloproteinase 2 - analysis
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 9 - analysis
Matrix Metalloproteinase 9 - metabolism
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Probability
Prognosis
Reference Values
Sensitivity and Specificity
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Summary:Objectives: Matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) are proteolytic enzymes that digest collagen type IV and other components of the basement membrane. They play a key role in local invasion and the formation of distant metastases by malignant tumors. The aim of this study was to evaluate the activity of MMP-2 and MMP-9 in stage III and IV laryngeal cancers. Study Design: In the study we used specimens of laryngeal cancer and surrounding normal mucosa obtained from 23 patients undergoing surgical treatment as a primary therapy. After extraction of MMP-2 and MMP-9 from tissue samples, their activity was assessed with zymography. Results: Greater activity of MMP-2 and MMP-9 and a higher active/latent MMP-2 ratio were found in cancer compared with normal mucosa. Moreover, N2 tumors revealed greater activity of MMP-2 in comparison with N1 and N0 tumors. Conclusions: Results of the study indicate that both MMP-2 and MMP-9 may be involved in the expansion of laryngeal cancer. MMP-2 may also play an important role in the lymphatic spread of some laryngeal tumors. (Otolaryngol Head Neck Surg 2003;128:132-6.)
ISSN:0194-5998
1097-6817
DOI:10.1067/mhn.2003.8