Abnormal expression of apoptosis‐related genes in haematological malignancies: overexpression of MYC is poor prognostic sign in mantle cell lymphoma

The expression of apoptosis‐related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real‐time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27), chronic myeloid leukaem...

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Published in:British journal of haematology 2003-02, Vol.120 (3), p.434-441
Main Authors: Nagy, Bálint, Lundán, Tuija, Larramendy, Marcelo L., Aalto, Yan, Zhu, Ying, Niini, Tarja, Edgren, Henrik, Ferrer, Anna, Vilpo, Juhani, Elonen, Erkki, Vettenranta, Kim, Franssila, Kaarle, Knuutila, Sakari
Format: Article
Language:English
Subjects:
Adult
Aged
Apoptosis - genetics
apoptotic genes
Biological and medical sciences
Biomarkers, Tumor - genetics
Child
Child, Preschool
Chromosomes, Human, Pair 11 - genetics
Female
Follow-Up Studies
Gene Deletion
Gene Expression
Genes, myc
haematological malignancies
Hematologic and hematopoietic diseases
Hematology
Humans
Immunophenotyping
Leukemia - genetics
Leukemia - immunology
Leukemia - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Mantle-Cell - genetics
Lymphoma, Mantle-Cell - immunology
Lymphoma, Mantle-Cell - pathology
Male
Medical sciences
Middle Aged
Prognosis
quantitative real‐time PCR
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
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Summary:The expression of apoptosis‐related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real‐time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27), chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL, n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33‐positive ALL, and in CD56‐positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2003.04121.x