Effect of Direct Injection of Melanin-Concentrating Hormone into the Paraventricular Nucleus: Further Evidence for a Stimulatory Role in the Adrenal Axis via SLC-1

Melanin‐concentrating hormone (MCH) is implicated in the control of a number of hormonal axes including the hypothalamic‐pituitary adrenal (HPA) axis. Previous studies have shown that there is evidence for both a stimulatory and an inhibitory action on the HPA axis; therefore, we attempted to furthe...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2003-03, Vol.15 (3), p.268-272
Main Authors: Kennedy, A. R., Todd, J. F., Dhillo, W. S., Seal, L. J., Ghatei, M. A., O'Toole, C. P., Jones, M., Witty, D., Winborne, K., Riley, G., Hervieu, G., Wilson, S., Bloom, S. R.
Format: Article
Language:English
Subjects:
adrenal
Adrenocorticotropic Hormone - blood
Animals
antagonist
Biological and medical sciences
Cells, Cultured
Corticosterone - blood
Corticotropin-Releasing Hormone - metabolism
CRF
Fundamental and applied biological sciences. Psychology
HPA
Hypothalamic Hormones - pharmacology
Hypothalamo-Hypophyseal System - cytology
Hypothalamo-Hypophyseal System - physiology
Injections, Intraventricular
Male
melanin-concentrating hormone
Melanins - pharmacology
Microinjections
Paraventricular Hypothalamic Nucleus - cytology
Paraventricular Hypothalamic Nucleus - drug effects
Paraventricular Hypothalamic Nucleus - physiology
Pituitary Hormones - pharmacology
Pituitary-Adrenal System - physiology
Rats
Rats, Wistar
Receptors, Somatostatin - antagonists & inhibitors
Receptors, Somatostatin - metabolism
stress
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Summary:Melanin‐concentrating hormone (MCH) is implicated in the control of a number of hormonal axes including the hypothalamic‐pituitary adrenal (HPA) axis. Previous studies have shown that there is evidence for both a stimulatory and an inhibitory action on the HPA axis; therefore, we attempted to further characterize the effects of MCH on this axis. Intracerebroventricular injection of MCH increased circulating adrenocorticotropic hormone (ACTH) at 10 min post injection. Injection of MCH directly into the paraventricular nucleus (PVN) was found to increase both circulating ACTH and corticosterone 10 min after injection. Additionally, MCH was found to increase corticotropin‐releasing factor (CRF) release from hypothalamic explants, and this effect was abolished by the specific SLC‐1 antagonist SB‐568849. Neuropeptide EI, a peptide from the same precursor as MCH was also found to increase CRF release from explants. These results suggest that MCH has a stimulatory role in the HPA axis via SLC‐1, and that MCH exerts its effects predominantly through the PVN CRF neuronal populations
ISSN:0953-8194
1365-2826
DOI:10.1046/j.1365-2826.2003.00997.x