Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats

The present study evaluated the beneficial effect of aqueous extract of garlic ( Allium sativum L.; 100 mg/kg/day) on the alterations in vascular reactivity of streptozotocin-diabetic rats. After 8 weeks of treatment, thoracic aortic rings of rats were mounted in organ baths and contractile response...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2003-03, Vol.85 (1), p.139-144
Main Authors: Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad, Homayounfar, Homayoun, Hosseini, Mahmoud
Format: Article
Language:English
Subjects:
Animals
Aorta
Aorta, Thoracic - drug effects
Aorta, Thoracic - physiopathology
Biological and medical sciences
Blood Glucose - analysis
Body Weight - drug effects
Diabetes mellitus
Diabetes Mellitus, Experimental - physiopathology
Dose-Response Relationship, Drug
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Garlic
General pharmacology
In Vitro Techniques
Male
Medical sciences
Muscle Contraction - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - physiopathology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Rat
Rats
Rats, Wistar
Vascular reactivity
Vasoconstriction - drug effects
Vasodilation - drug effects
Water
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Summary:The present study evaluated the beneficial effect of aqueous extract of garlic ( Allium sativum L.; 100 mg/kg/day) on the alterations in vascular reactivity of streptozotocin-diabetic rats. After 8 weeks of treatment, thoracic aortic rings of rats were mounted in organ baths and contractile responses to phenylephrine and relaxant responses to acetylcholine and isosorbide dinitrate were assessed. Induction of diabetes significantly increased contractile responses to phenylephrine and impaired endothelium-dependent relaxations to acetylcholine in aortic rings, but did not change endothelium-independent relaxation to isosorbide dinitrate. Garlic administration significantly improved the impaired endothelium-dependent relaxations and decreased the enhanced contractile response to phenylephrine in diabetic rats. It is concluded that intraperitoneal administration of aqueous garlic extract can improve endothelial dysfunction in insulin-dependent model of uncontrolled diabetes.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(02)00372-0