Serum α-tocopherol and ascorbic acid concentrations in Type 1 and Type 2 diabetic patients with and without angiopathy

Background: Alpha-tocopherol and ascorbic acid form a part of scavenger system influencing the level of oxidative stress in diabetes mellitus. The aim of this study was to evaluate serum concentrations of α-tocopherol and ascorbic acid in Type 1 and Type 2 diabetes mellitus and to compare them with...

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Bibliographic Details
Published in:Clinica chimica acta 2003-03, Vol.329 (1), p.103-108
Main Authors: SKRHA, Jan, PRAZNY, Martin, HILGERTOVA, Jirina, WEISEROVA, Hana
Format: Article
Language:English
Subjects:
Acetylglucosamine - metabolism
Adolescent
Adult
Antioxidants - metabolism
Ascorbic acid
Ascorbic Acid - blood
Associated diseases and complications
Biological and medical sciences
Cholesterol - blood
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Diabetic Angiopathies - blood
Diabetic angiopathy
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Humans
Lipids - blood
Male
Malondialdehyde - blood
Medical sciences
Oxidative stress
Oxidative Stress - physiology
Serum Albumin - analysis
Serum Albumin - metabolism
Triglycerides - blood
Vitamin E - blood
α-Tocopherol
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Summary:Background: Alpha-tocopherol and ascorbic acid form a part of scavenger system influencing the level of oxidative stress in diabetes mellitus. The aim of this study was to evaluate serum concentrations of α-tocopherol and ascorbic acid in Type 1 and Type 2 diabetes mellitus and to compare them with the presence of vascular complications as well as with oxidative stress and endothelial dysfunction. Methods: A total of 38 Type 1 and 62 Type 2 diabetic patients were subdivided into those with and without angiopathy. Serum α-tocopherol and ascorbic acid concentrations were estimated in all patients and in 38 healthy persons. Their results were compared with diabetes control, with oxidative stress measured by plasma malondialdehyde and with endothelial dysfunction estimated by serum N-acetyl-β-glucosaminidase activity. In addition, the differences in biochemical variables were compared between patients with and without angiopathy. Results: Serum α-tocopherol related to the sum of cholesterol and triglyceride concentrations (AT/CHT ratio) was significantly lower in diabetic patients with macroangiopathy than in those without vascular changes ( p
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(03)00007-X