The influence of serum leptin concentration on bone mass assessed by quantitative ultrasonometry in pre and postmenopausal women

Objective: the aim of this study was to evaluate the influence of serum leptin concentration on bone mass assessed by quantitative ultrasound (QUS) in a large sample of healthy pre and postmenopausal women. Design: 555 healthy pre and postmenopausal ( n=261 and n=294) women (mean age, 49.5±17.2 year...

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Bibliographic Details
Published in:Maturitas 2003-02, Vol.44 (2), p.141-148
Main Authors: Hadji, P, Bock, K, Gotschalk, M, Hars, O, Backhus, J, Emons, G, Schulz, K.-D
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Body Mass Index
Bone Density - physiology
Bone mass
Diseases of the osteoarticular system
Estradiol - blood
Female
Germany - epidemiology
Humans
Leptin
Leptin - blood
Medical sciences
Menopause
Menopause - physiology
Middle Aged
Osteoporosis
Osteoporosis, Postmenopausal - blood
Osteoporosis, Postmenopausal - diagnostic imaging
Osteoporosis, Postmenopausal - epidemiology
Osteoporosis, Postmenopausal - etiology
Osteoporosis. Osteomalacia. Paget disease
Regression Analysis
Surveys and Questionnaires
Ultrasonography
Ultrasonometry
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Summary:Objective: the aim of this study was to evaluate the influence of serum leptin concentration on bone mass assessed by quantitative ultrasound (QUS) in a large sample of healthy pre and postmenopausal women. Design: 555 healthy pre and postmenopausal ( n=261 and n=294) women (mean age, 49.5±17.2 years) not on hormone replacement therapy were recruited on the occasion of a routine gynecological visit. Before entry to the study, all women had answered a detailed questionnaire on important risk factors and gave written informed consent. Speed of sound (SOS), broadband ultrasound attenuation (BUA) and stiffness index (SI) of the os Calcis were measured using the Achilles ultrasonometer (GE/lunar). We systematically investigated the relation of menopause, BMI and leptin on bone mass by allocating women into the following groups: (a) premenopausal women BMI25 kg/m 2 ( N=83); (c) postmenopausal women BMI25 kg/m 2 ( N=169). Additionally we investigated the relation of serum leptin concentrations, age and BMI on ultrasonometry variables by performing a multiple linear regression analyses. Results: in the initial analyses premenopausal women showed a significantly ( P25 kg/m 2 had significantly higher leptin concentrations ( P
ISSN:0378-5122
1873-4111
DOI:10.1016/S0378-5122(02)00324-9